Recombinant Human IL-16

IL-16是一种CD8 + T cell-derived细胞因子,趋化性的CD4 + T细胞和CD4 +单核细胞和嗜酸性粒细胞。凝胶过滤的分析表明,在生理条件下,主要存在hIL-16 noncovalently链多聚体,但一些IL-16可能存在单体。重组人类IL-16 12.4 kDa蛋白由121个氨基酸残基组成。使用所有无动物生产试剂。

一.产品名称：Recombinant Human IL-16 (121 a.a.)/重组IL-16

二.Catalog Number:AF-200-16A

三.Synonyms:LCF (Lymphocyte Chemoattractant Factor)

四.Description:

IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 12.4 kDa protein consisting of 121 amino acid residues. . Manufactured using all non-animal reagents.

五.AA Sequence:

SAASASAASD VSVESTAEAT VCTVTLEKMS AGLGFSLEGG KGSLHGDKPL TINRIFKGAA SEQSETVQPG DEILQLGGTA MQGLTRFEAW NIIKALPDGP VTIVIRRKSL QSKETTAAGD S

六.Source:E.coli

七.Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.Biological Activity:

Determined by its ability to chemoattract human peripheral blood lymphocytes using a concentration range of 50.0-1000.0 ng/ml.

九.Cross Reactivity:Mouse