Recombinant Human GM-CSF

GM-CSF的造血生长因子刺激中性粒细胞和巨噬细胞的发展和促进早期的扩散和发展红色的巨核细胞和嗜酸性粒细胞的祖细胞。生产的内皮细胞,单核细胞、成纤维细胞和淋巴细胞。gm - csf抑制中性粒细胞迁移和增强的功能活动end-cells成熟。人类和小鼠分子具有种特异性,表现出没有跨物种反应性。

一.产品名称：Recombinant Human GM-CSF

二.产地：Peprotech公司

三.货号Catalog Number:AF-300-03

四.同义Synonyms:Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha

五.描述Description:

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Manufactured using all non-animal reagents.

六.AA序列AA Sequence:

MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

七.来源Source:E.coli

八.纯度Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

九.活性Biological Activity:

The ED₅₀ was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷ units/mg.

十.交叉性Cross Reactivity:Human, Mouse