Recombinant Human BMP-4

骨形成蛋白(bmp)构成一个亚科内TGF-β总科的结构相关信号蛋白。这个总科的成员广泛分布于整个身体,并参与各种生理过程在两个前和产后的生活。像BMP-7 BMP-4参与骨骼和软骨的开发和维护。BMP-4表达降低与许多骨相关疾病。

一.产品名称：Recombinant Human BMP-4

二.货号Catalog Number:AF-120-05ET

三.同义Synonyms:BMP-2B, DVR4

四.描述Description:

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body, and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. PeproTech’s E.coli-derived BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits, which correspond to amino acids 303-408 of the full length BMP-4 precursor.  The calculated molecular weight of Recombinant Human BMP-4 (E.coli-derived) is 23.9 kDa. Manufactured using all non-animal reagents.

五.AA序列AA Sequence:

KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPSAIS MLYLDEYDKV VLKNYQEMVV EGCGCR

六.来源Source:E.coli

Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

七.生物活性Biological Activity:

Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED₅₀ for this effect is 5-10 ng/ml.

八.交叉性Cross Reactivity:Mouse, Human, Rat