Recombinant Human BDNF

脑源性神经营养因子是神经生长因子家族的成员。和这个家庭的其他成员一样,BDNF支持神经元增殖和生存。脑源性神经营养因子可以绑定一个细胞表面受体称为LNGFR低亲和力,也将其他neurotrophins如神经生长因子、NT-3 NT-4。

一.产品名称：Recombinant Human BDNF

二.货号Catalog Number:AF-450-02

三.同义Synonyms:Brain Derived Neurotrophic Factor, Abrineurin

四.描述Description:

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical. Manufactured using all non-animal reagents.

五.AA序列AA Sequence:

MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR

六.来源Source:E.coli

七.纯度Purity:Greater than 98% by SDS-PAGE gel and HPLC analyses.

八.生物活性Biological Activity:

Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED₅₀ for this effect is 0.5-1.0 μg/ml.

九.交叉反应性Cross Reactivity:

Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat, Human