TMR-ShK (TMR-Stichodactyla toxin)

Fluorescent (red) K_v1.3 blocker

钾离子通道K_v1.3阻断剂（红色荧光）

TMR-ShK peptide toxin is a synthetic derivative of the well-known ShK toxin (Stichodactyla helianthus neurotoxin) isolated from the venom of the Carribean sea anemone Stoichactis helianthus. Wild-type ShK blocks potently K_v1.3 (KCNA3), K_v1.1 (KCNA1), K_v1.4 (KCNA4) and K_v1.6 (KCNA6) with a Kd value of 11 pM, 16 pM, 312 pM and 165 pM, respectively. The fluorescent TMR-labeled ShK blocks K_v1.3 and K_v1.1 with Kd values of 52 pM and 397 pM, respectively. TMR-ShK can be used to identify lymphocytes expressing K_v1.3 channels such as effective memory T cells (TEM) in the case of autoimmune diseases (type 1 diabetes, mellitus or rheumatoid arthritis) which overexpress K_v1.3 channels.

TMR-Shk 技术资料

氨基酸序列：TMR-AEEAc-Arg-Ser-Cys³-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys¹²-Thr-Ala-Phe-Gln-Cys¹⁷-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys²⁸-Arg-Lys-Thr-Cys³²-Gly-Thr-Cys³⁵-OH

二硫键： Cys³-Cys³⁵, Cys¹²-Cys²⁸ and Cys¹⁷-Cys³² 

长度（aa）:35

分子式：C₂₀₀H₃₁₀N₅₇O₅₅S₇ 

分子量：4611.7 Da

外观：red lyophilized solid

可溶性：water or saline buffer

CAS号： NA

来源：Synthetic

纯度：> 97% 

TMR fluorescent dye (5(6)-TAMRA): λ_ex543nM,  λ_em572nM

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