011PUR001Purotoxin-1
【简单介绍】
【详细说明】
Purotoxin-1
Selective inhibitor of P2X3 receptors
ATP离子通道P2X3受体选择性抑制剂
Therapeutic interest : painPurotoxin-1 (PT-1) is a peptide originally isolated from the Central Asian spider Geolycosa sp. was shown to inhibit selectively P2X3 receptor channels at a 100 nM concentration. Studies were carried-out on cultured rat DRG neurons. Patch-clamp experiments did not show any inhibitory effect of PT-1 on voltage-gated channels (potentials range tested from -100 to 20 mV), neither on TRPV1 (after activation with 500 nM capsaicin). The selectivity of for P2X3 was highlighted by activating this receptor with 10 µM ATP and 100 µM α, β Methylene-ATP. Indeed, unlike P2X3, P2X2 and heterodimer P2X2/3 are known to be not sensitive to such concentrations. Moreover, P2X3, P2X2, and P2X2/3 are the only known ATP-sensitive receptors expressed in plasma membranes of DRG neurons. So, the observed effect seems to be well related to a selective inhibition of P2X3. P2X3-mediated current was fully inhibited with 100 nM, making it the most potent and selective ligand for P2X3.
P2X3 receptors are known to be implicated in pain mechanisms. Behavioral experimentations carried-out on rat pain models using 0.5 nmol PT-1 injected intraplantar showed to reduce nociception. This anti-nociceptive effect is comparable to A-317491 compound (Abbott's drug) with an amount of almost 3 orders of magnitude lower.
技术资料
氨基酸序列:
Gly-Tyr-Cys3-Ala-Glu-Lys-Gly-Ile-Arg-Cys10-Asp-Asp-Ile-His-Cys15-Cys16-Thr-Gly-Leu-Lys-Cys21-Lys-Cys23-Asn-Ala-Ser-Gly-Tyr-Asn-Cys30-Val-Cys32-Arg-Lys-Lys-NH2
二硫键:Cys3-Cys16; Cys10-Cys21; Cys15-Cys32; Cys23-Cys30
长度 (aa): 35
分子式:C155H248N50O48S8
分子量: 3834.59 Da
外观:White lyophilized solid
可溶性: water and saline buffer
CAS 号:not available
来源: Synthetic
纯度: > 97 %
产品信息
011PUR001-00100 | Purotoxin 1 | 0.1mg |
011PUR001-00500 | Purotoxin 1 | 0.5mg |
011PUR001-01000 | Purotoxin 1 | 1mg |
相关产品
- smartox 多肽毒素
- ADT001-00010AdTx1 (rho-Da1a – ρ-Da1b)
- BPX001-01000β-Pompilidotoxin
- WAG002Waglerin-1-FAM (羧基荧光素标记Waglerin-1)
- PTX003ProTx-III,新的选择性Nav1.7通道阻断剂
- OD1,有效的Nav1.7通道激活剂
- NMB001NMB-1
- MTX007-00100MT7 – Muscarinic Toxin 7(毒蕈碱毒素7)
- MEL01Melittin 蜂毒肽,蜂毒素
- MAM001-50010Mambalgin-1
- LED01-00100Leiuorotoxin-Dab7 (Lei-Dab7)
- Huwentoxin-XVI
- CRO001Crotamine响尾蛇胺
- 10VAN003Vanillotoxin 3(VaTx3)
- SAT001TMR-ShK (TMR-Stichodactyla toxin)
- 08TER001Tertiapin-Q
- 10TAM001Tamapin
- SCT01Stromatoxin-1 / ScTx1
- 08SHK001Stichodactyla toxin(ShK)
- 011PUR001Purotoxin-1
- 13PCT001Psalmotoxin 1/ PcTx1
- 07PTX002Protoxin II / ProTx-II
- 12PTX001Protoxin I / ProTx-I
- 13PHX003Phrixotoxin-3 /Paurtx-3
- PHX002-50010Phrixotoxin-2 / PaTx2
- 10OBT001Obtustatin
- 11CAS001Morphiceptin(吗啡感受素:阿片μ受体激动剂)
- 08MAR001Maurotoxin
- 07MAU001Maurocalcine
- 11CON014Lys-conopressin G(加压素样肽)
- 10LEI001Leiurotoxin 1 / Scyllatoxin
- 08NEU001HsTx-1
- 11GUA002Guangxitoxin 1E(GxTx-1E)
- 08GSM001GsMTx4
- 12GSF002GsAF-II
- 12GSF001GsAF-I
- 10GTX002GaTx2
- 13GTX001GaTx1
- 08CON009Conantokin-G(芋螺抑制肽-G)
- 11CHA001Charybdotoxin /ChTx
请输入产品关键字:
邮编:100083
联系人:尤女士
电话:4008858216
传真:
手机:13581534696
留言:发送留言
个性化:www.qbiotec.com
网址:www.qbiotec.com
商铺:https://www.chem17.com/st289923/