13PCT001Psalmotoxin 1/ PcTx1
【简单介绍】
【详细说明】
Psalmotoxin 1 /PcTx1
ASIC1a selective blocker(酸敏感通道ASIC1a选择性阻断剂)
Psalmotoxin-1 (PcTx1, Pi-theraphotoxin-Pc1a) has been isolated from the venom of the Spider Psalmopoeus cambridgei (Trinidad chevron tarantula). PcTx1 is known to block potently (IC50 = 1 nM) and selectively the H+-gated sodium channel ASIC1a (acid-sensitive ion channel 1a). The blockage is rapid and reversible. PcTx1 can distinguish between the two ASIC1 splice variants ASIC1a and ASIC1b. PcTx1 loses its capacity to block ASIC1a as soon as this subunit is associated with another member of the family (ASIC2a or ASIC3). PcTx1 demonstrates an analgesic effect in acute and neuropathic pain models.
PcTx1技术资料
氨基酸序列:Glu-Asp-Cys3-Ile-Pro-Lys-Trp-Lys-Gly-Cys10-Val-Asn-Arg-His-Gly-Asp-Cys17-Cys18-Glu-Gly-Leu-Glu-Cys23-Trp-Lys-Arg-Arg-Arg-Ser-Phe-Glu-Val-Cys33-Val-Pro-Lys-Thr-Pro-Lys-Thr
二硫键:Cys3-Cys18, Cys10-Cys23 and Cys17-Cys33
长度 (aa): 40
分子式: C200H312N62O57S 6
分子量: 4690.82 Da
外观:White lyophilized solid
可溶性: water and saline buffer
CAS 号:not available
来源:Synthetic
纯度: > 98%
产品信息
13PCT001-00100 | PcTx1 | 0.1mg |
13PCT001-00500 | PcTx1 | 0.5mg |
13PCT001-01000 | PcTx1 | 1mg |
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