07MAU001Maurocalcine

Maurocalcine  

Agonist of ryanodine receptors(鱼尼丁受体激动剂)

 Maurocalcine, a component of the venom of Scorpio maurus palmatus, was discovered by Michel De Waard, co-founder of Smartox.  folds according to an inhibitor cysteine knot. Such as Imperatoxin A,  acts as a high affinity agonist of the type-1 ryanodine receptorexpressed in skeletal muscles with an affinity in the 10 nM range.  induces an increase in channel opening probability accompanied by sudden transitions to long lasting subconductance states.  has also been characterized as a cell penetrating peptide and its pharmacological activity can be observed upon extracellular perfusion.

技术资料

氨基酸序列：

Gly-Asp-Cys³-Leu-Pro-His-Leu-Lys-Leu-Cys¹⁰-Lys-Glu-Asn-Lys-Asp-Cys¹⁶-Cys¹⁷-Ser-Lys-Lys-Cys²¹-Lys-Arg-Arg-Gly-Thr-Asn-Ile-Glu-Lys-Arg-Cys³²-Arg-OH 

二硫键： Cys³-Cys¹⁷, Cys¹⁰-Cys²¹ and Cys¹⁶-Cys³² 

长度 (aa)：33

分子式： C₁₅₆H₂₆₀N₅₆O₄₆S ₆ 

分子量： 3858.8 Da

外观： White lyophilized solid

可溶性： water and saline buffer

CAS 号：not available

来源：Synthetic 

纯度： > 98 %

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