PHX002-50010Phrixotoxin-2 / PaTx2

Phrixotoxin-2 / PaTx2 

Blocker of K_v4.2 and K_v4.3 channels(钾离子通道K_v4.2 和K_v4.3阻断剂)

Phrixotoxin-2 (PaTx2) has been isolated originally from the venom of the Chile fire tarantula Phrixotrichus auratus. Phrixotoxin-2 is a 31 amino acid peptide that contains three disulphide bridges. Phrixotoxin-2 specifically blocks recombinant K_v4.2 and K_v4.3 currents with IC₅₀ values of 34 nM and 71 nM, respectively. It does so by altering the gating properties of the channels. The inhibition of K_v4.2 and K_v4.3 currents is fully reversible upon washout. K_v4.1 is only slightly sensitive to Phrixotoxin-2 (maximal block of 20 by 300 nM). K_v1, K_v2 and K_v3 channel subfamilies are insensitive to this toxin.

Phrixotoxin-2 技术资料

氨基酸序列：Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Glu-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Leu-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Arg-Ile-Ile-Asn-Met-NH₂ 

二硫键：Cys²-Cys¹⁶, Cys⁹-Cys²¹ and Cys¹⁵-Cys²⁵ 

长度 (aa)： 31

分子式： C₁₆₉H₂₅₉N₄₉O₄₃S₈ 

分子量：  3921.71 Da

外观：white lyophilized solid

可溶性：water or saline buffer

CAS 号：221889-63-0 

来源：Synthetic

纯度：> 98%

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