10TAM001Tamapin
【简单介绍】
【详细说明】
Tamapin
Selective blocker of SK2 (KCa2.2) channels
SK2 (KCa2.2)通道选择性阻断剂
Tamapin is a peptide toxin isolated from the venom of the Indian red scorpion Mesobuthus Tamulus. is amidated at its C-terminal tyrosine residue. binds to small conductance Ca2+-activated K+ channels (SK channels) with high affinity and inhibits SK channel-mediated currents in pyramidal neurons of the hippocampus as well as in cell lines expressing distinct SK channel subunits. Contrary to Apamin or Leiurotoxin-1 (Scyllatoxin), is an excellent toxin to discriminate among SK channel subtypes because it presents different affinities for SK1 (42 nM), SK2 (24 pM) and SK3 (1.7 nM) channels. This toxin is also the most potent SK2 channel blocker characterized so far (IC50 for SK2 channels = 24 pM).
技术资料
氨基酸序列:
Ala-Phe-Cys3-Asn-Leu-Arg-Arg-Cys8-Glu-Leu-Ser-Cys12-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys21 -Ile-Gly-Glu-Glu-Cys26-Lys -Cys28-Val-Pro-Tyr-NH2
二硫键: Cys3-Cys21; Cys8-Cys26; Cys12-Cys28
长度(aa): 31
分子式:C146H237N44O41S6
分子量: 3459.00 Da
外观:White lyophilized solid
可溶性: water and saline buffer
CAS号: not available
来源:Synthetic
纯度:> 97 %
产品信息
10TAM001-00100 | 0.1mg | |
10TAM001-00500 | 0.5mg | |
10TAM001-01000 | 1mg |
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