07PTX002Protoxin II / ProTx-II
【简单介绍】
【详细说明】
Protoxin II / ProTx-II
Nav1.7 selective inhibitor(钠离子通道Nav1.7选择性抑制剂)
ProTx-II (ProTx-2, Protoxin II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula). ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant voltage-gated sodium channels.ProTx-II inhibits activation by shifting the voltage-dependence of channel activation to more positive potentials. ProTx-II blocks Nav1.7 with an IC50 value of around 300 pM, Nav1.2, Nav1.5 and Nav1.6 with IC50 values of 41 nM, 79 nM and 26 nM respectively. It also acts on Cav3.1/CACNA1G and interacts more weakly with the related T-Type channel Cav3.2/CACNA1H but potently inhibits the L-type calcium channel Cav1.2/CACNA1C. ProTx-II blocks action potential propagation in nociceptors.
ProTx-II 技术资料
氨基酸序列:
Tyr-Cys2-Gln-Lys-Trp-Met-Trp-Thr-Cys9-Asp-Ser-Glu-Arg-Lys-Cys15-Cys16-Glu-Gly-Met-Val-Cys21-Arg-Leu-Trp-Cys25-Lys-Lys-Lys-Leu-Trp-OH
二硫键:Cys2-Cys16, Cys9-Cys21 and Cys15-Cys25
长度 (aa): 30
分子式: C168H250N46O41S8
分子量:3828.00 Da
外观: White lyophilized solid
可溶性:water and saline buffer
CAS 号:484598-36-9
来源: Synthetic
纯度:> 95 %
产品信息
07PTX002-00100 | ProTx-II | 0.1mg |
07PTX002-00500 | ProTx-II | 0.5mg |
07PTX002-01000 | ProTx-II | 1mg |
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