Maurotoxin  

Maurotoxin Kv and SK channels blocker

Kv和SK通道阻断剂（SK：小电导钙激活的钾通道）

 is a component of the venom of Scorpio maurus palmatus.  is a member of the α-KTx6.2 scorpion toxin family. It blocks voltage-gated potassium channels (K_V1.1/KCNA1, K_V1.2/KCNA2, and K_V1.3/KCNA3) and inhibits apamin-sensitive small conductance calcium-activated channels (SK channels), particularly K_Ca3.1 (IKca1, SK4). The blockage of K_v1.2 occurs with high affinity.

技术资料

氨基酸序列：

Val-Ser-Cys³-Thr-Gly-Ser-Lys-Asp-Cys⁹-Tyr-Ala-Pro-Cys¹³-Arg-Lys-Gln-Thr-Gly-Cys¹⁹-Pro-Asn-Ala-Lys-Cys²⁴-Ile-Asn-Lys-Ser-Cys²⁹-Lys-Cys³¹-Tyr-Gly-Cys³⁴-NH₂ 

二硫键：Cys³-Cys²⁴, Cys⁹-Cys²⁹, Cys¹³-Cys¹⁹ and Cys³¹ -Cys³⁴ 

长度 (aa)：34 

分子式：C₁₄₅H₂₃₁N₄₅O₄₇S₈ 

分子量：3612.55 Da 

外观：White lyophilized solid 

可溶性：water or saline buffer 

CAS 号：not available 

来源：Synthetic  

纯度：> 95 %

产品信息