鼠抗人BOB.1单克隆抗体

鼠抗人BOB.1单克隆抗体

广州健仑生物科技有限公司

BOB.1又称OCA-B或OBF-1，是B淋巴细胞的特异性核转录因子协调刺激物，是B细胞免疫球蛋白基因表达所需要的转录因子，通常表达在B淋巴细胞核中，包括浆细胞。BOB.1显示出B细胞特异表达模式，与B细胞的活化及发生中心的形成有密切关系。同时，BOB.1在T淋巴细胞也具有基因转录调节的作用。抗体BOB.1常用于B细胞淋巴瘤和结节样淋巴细胞性何杰金淋巴瘤的诊断。一些T细胞淋巴瘤亦可出现BOB.1阳性。

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【产品介绍】

细胞定位：细胞核

克隆号：MRQ-35

同型：IgG2b

适用组织：石蜡/冰冻

阳性对照：B细胞淋巴瘤/霍奇金氏淋巴瘤/扁桃体

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

更高级的应用主要有以下几个方面：
因酿酒酵母与同为真核生物的动物和植物细胞具有很多相同的结构，又容易培养，酵母被用作研究真核生物的模式生物，也是目前被人们了解zui多的生物之一。在人体中重要的蛋白质很多都是在酵母中先被发现其同源物的，其中包括有关细胞周期的蛋白、信号蛋白和蛋白质加工酶。
酿酒酵母也是制作培养基中常用成分酵母提取物的主要原料。
酵母作为高等真核生物特别是人类基因组研究的模式生物，其zui直接的作用体现在生物信息学领域。当人们发现了一个功能未知的人类新基因时，可以迅速地到任何一个酵母基因组数据库中检索与之同源的功能已知的酵母基因，并获得其功能方面的相关信息，从而加快对该人类基因的功能研究。研究发现，有许多涉及遗传性疾病的基因均与酵母基因具有很高的同源性，研究这些基因编码的蛋白质的生理功能及它们与其它蛋白质之间的相互作用将有助于加深对这些遗传性疾病的了解。此外，人类许多重要的疾病，如早期糖尿病、小肠癌和心脏疾病，均是多基因遗传性疾病，揭示涉及这些疾病的所有相关基因是一个困难而漫长的过程，酵母基因与人类多基因遗传性疾病相关基因之间的相似性将为人类提高诊断和治疗水平提供重要的帮助。
酵母作为模式生物的例子体现在那些通过连锁分析、定位克隆然后测序验证而获得的人类遗传性疾病相关基因的研究中，后者的核苷酸序列与酵母基因的同源性为其功能研究提供了*的线索。例如，人类遗传性非息肉性小肠癌相关基因与酵母的MLH1、MSH2基因，运动失调性毛细血管扩张症相关基因与酵母的1基因，布卢姆氏综合征相关基因与酵母的SGS1基因，都有很高的同源性。遗传性非息肉性小肠癌基因在肿瘤细胞中表现出核苷酸短重复顺序不稳定的细胞表型，而在该人类基因被克隆以前，研究工作者在酵母中分离到具有相同表型的基因突变（msh2和mlh1突变）。受这个结果启发，人们推测小肠癌基因是MSH2和MLH1的同源基因，而它们在核苷酸序列上的同源性则进一步证实了这一推测。布卢姆氏综合征是一种临床表现为性早熟的遗传性疾病，病人的细胞在体外培养时表现出生命周期缩短的表型，而其相关基因则与酵母中编码蜗牛酶的SGS1基因具有很高的同源性。与来自布卢姆氏综合征个体的培养细胞相似，SGS1基因突变的酵母细胞表现出显著缩短的生命周期。Francoise等研究了170多个通过功能克隆得到的人类基因，发现它们中有42%与酵母基因具有明显的同源性，这些人类基因的编码产物大部分与信号转导途径、膜运输或者DNA合成与修复有关，而那些与酵母基因没有明显同源性的人类基因主要编码一些膜受体、血液或免疫系统组分，或人类特殊代谢途径中某些重要的酶和蛋白质。

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

想了解更多的产品及服务请扫描下方二维码：

【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

More advanced applications mainly in the following areas:
Because Saccharomyces cerevisiae has many of the same structures as eukaryotic animals and plant cells and is easy to grow, yeast is used as a model organism for the study of eukaryotes and is one of the most widely understood organisms. Many of the proteins that are important in the body are first found in yeast, including the cell cycle-related proteins, signaling proteins and protein processing enzymes.
Saccharomyces cerevisiae is also the main raw material for producing yeast extract which is commonly used in the culture medium.
Yeast, as a model organism for higher eukaryotes, especially human genomics, has the most direct role in bioinformatics. When one finds a new human gene of unknown function, one can quickly search any one of the yeast genome databases for homologous, well-known yeast genes and gain information on their function to speed up the human Functional studies of genes. The study found that many genes involved in genetic diseases share high homology with yeast genes and that studying the physiological functions of the proteins encoded by these genes and their interactions with other proteins will help deepen the understanding of these genetic Understanding of sexually transmitted diseases. In addition, many important human diseases, such as early stage diabetes, small intestine cancer and heart disease, are polygenic inherited diseases. It is a difficult and lengthy process to reveal all the related genes involved in these diseases. Yeast gene and human polygenic inheritance The similarity between disease-related genes will provide important help for human to improve the level of diagnosis and treatment.
The best examples of yeast as a model organism are embodied in studies of human genetic disease-related genes obtained by linkage analysis, positional cloning and sequencing validation, whose homology to the yeast genes is their function Research provides excellent clues. For example, human hereditary non-polyposis colorectal cancer-related genes and yeast MLH1, MSH2 gene, motor-related angiectasia related genes and yeast 1 gene, Bloom syndrome-related genes and yeast SGS1 gene, both High homology. Hereditary nonpolyposis colorectal cancer genes exhibit a short-stranded nucleotide sequence that is unstable in tumor cells, and before the human gene was cloned, researchers isolated genes with the same phenotype in yeast Mutations (msh2 and mlh1 mutations). Inspired by this result, it is speculated that the small intestine oncogene is a homologue of MSH2 and MLH1, and their homology to nucleotide sequences further confirms this conjecture. Bloom's syndrome is a hereditary disease characterized by precocious puberty. Cells from patients show a shortened life-cycle phenotype when cultured in vitro, while their genes are associated with the SGS1 gene encoding snail amylase in yeast High homology. Similar to the cultured cells from individuals with Bloom syndrome, SGS1 mutant yeast cells showed a significantly shortened life cycle. Francoise et al. Studied more than 170 human genes cloned by function and found that 42% of them have obvious homology with yeast genes. Most of the coding products of these human genes are involved in signal transduction pathway, membrane trafficking or DNA synthesis Is involved in repair, while those human genes that have no significant homology to the yeast gene encode primarily membrane receptors, components of the blood or immune system, or certain important enzymes and proteins in the special metabolic pathways of humans.