ω-Conotoxin MVIIC / Omega conotoxin MVIIC (ω-漏斗网蛛毒素MVIIC)  

Blocker of P/Q and N-type Ca²⁺ channels

P/Q型钙通道和N型钙通道阻断剂

ω-conotoxin MVIIC (omega conotoxin MVIIC) has been isolated from the venom of the cone Conus magus. ω-conotoxin MVIIC is a blocker of P/Q and N-type calcium channels. It inhibits presynaptic Ca²⁺ channels, including the Ca²⁺ channels responsible for Ca²⁺ uptake by rat brain synaptosomes, the P-type Ca²⁺ channels in cerebellar Purkinje cells, and a significant fraction of  ω-conotoxin GVIA-resistant currents in hippocampal CA1 neurons. ω-conotoxin MVIIC also presents an inhibition of  ω-conotoxin GVIA-resistant depolarization-induced neurotransmitter release in cerebellar neurons of rats. 

ω-conotoxin MVIIC (ω-漏斗网蛛毒素MVIIC)  技术资料

氨基酸序列：

 Cys¹-Lys-Gly-Lys-Gly-Ala-Pro-Cys⁸-Arg-Lys-Thr-Met-Tyr-Asp-Cys¹⁵-Cys¹⁶-Ser-Gly-Ser-Cys²⁰-Gly-Arg-Arg-Gly-Lys-Cys²⁶-NH₂ 
二硫键：Cys¹-Cys¹⁶, Cys⁸-Cys²⁰ and Cys¹⁵-Cys²⁶ 
长度 (aa)：26
分子式：C₁₀₆H₁₇₈N₄₀O₃₂S₇ 
分子量：2750.20 Da
外观：White lyophilized solid
可溶性：water and saline buffer
CAS 号：[147794-23-8]
来源： Synthetic 
纯度： > 97 %

产品信息