12HTX001Hainantoxin-IV(海南捕鸟蛛毒素-IV)
【简单介绍】
【详细说明】
Hainantoxin-IV(海南捕鸟蛛毒素-IV)
Selective blocker of TTX-S VGSC(电压门控钠离子通道TTX-S选择性阻断剂)
Hainantoxin-IV (HNTX-IV) is a peptide that was originally isolated from the venom of the Chinese bird spiderOrnithoctonus hainana Liang (Selenocosmia hainana Liang). It has been reported that this peptide is a potent antagonist of tetrodotoxin-sensitive (TTX-S) voltage-gated sodium channels (VGSCs). Hainantoxin-IV binds to TTX-S with an IC50value of 34 nM in adult rat dorsal root ganglion (DRG) neurons. Tetrodotoxin-resistant (TTX-R) voltage-gated sodium channels are not affected by Hainantoxin-IV. It probably interacts with the site 1 through a mechanism quite similar to that of TTX without affecting the activation and inactivation kinetics.
Hainantoxin-IV技术资料
氨基酸序列:
Glu-Cys2-Leu-Gly-Phe-Gly-Lys-Gly-Cys9-Asn-Pro-Ser-Asn-Asp-Gln-Cys16-Cys17-Lys-Ser-Ser-Asn-Leu-Val-Cys24-Ser-Arg-Lys-His-Arg-Trp-Cys31-Lys-Tyr-Glu-Ile-NH2
二硫键: Disulfide bonds between Cys2-Cys17, Cys9-Cys24, and Cys16-Cys31
长度 (aa): 35
分子式:C166H257N53O50S6
分子量: 3987.6 Da
外观:White lyophilized solid
可溶性:water and saline buffer
CAS 号:Not available
来源:Synthetic
纯度:> 97%
产品信息
12HTX001-00100 | Hainantoxin IV | 0.1mg |
12HTX001-00500 | Hainantoxin IV | 0.5mg |
12HTX001-01000 | Hainantoxin IV | 1mg |
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