商品信息

产品英文名称	Anti-α-Tubulin Monoclonal Antibody (3G5)
产品中文名称	α-Tubulin单克隆抗体（3G5）
别名	TUBA1A; Tubulin alpha-1A chain; Alpha-tubulin 3; Tubulin B-alpha-1; Tubulin alpha-3 chain

商品属性

克隆类型	单克隆
检测类型	IF,IP,WB,IHC-P
反应性	小鼠,人,大鼠
宿主	小鼠
免疫原	重组蛋白
产品形式	液体形式
基因ID	7846/10376
目标条带分子量	52
蛋白序列链接	/uniprot/Q71U36
存储缓冲液	PBS缓冲液（pH 7.4），含有0.5%BSA（稳定剂），0.02％（防腐剂）和50％甘油。
保存建议	自发货之日起，-20°C可稳定保存1年。为限度的避免损失，请在打开管盖之前融化抗体并离心。我们建议使用前分装以避免反复冻融。
运输条件	冰袋运输（蓝冰）
警告	本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为，我们不承担任何责任。

附加信息

背景

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulins. The genes encoding these microtubule constituents belong to the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes, which are highly conserved among species. TUBA1A encodes alpha tubulin and is highly similar to the mouse and rat Tuba1 genes. Northern blotting studies have shown that TUBA1A expression is predominantly found in morphologically differentiated neurologic cells. TUBA1A is one of three alpha-tubulin genes in a cluster on chromosome 12q. Mutations in TUBA1A cause lissencephaly type 3 (LIS3) - a neurological condition characterized by microcephaly, mental retardation, and early-onset epilepsy and caused by defective neuronal migration. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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