塔望科技提供全系列的动物实验用低/高氧控制产品，包括恒定浓度控制的低氧动物箱、高氧动物箱、可编程的间歇氧浓度控制系统、带缓冲闸的低氧箱等。整套低氧/高氧实验箱装置主要由氧气控制器和动物实验箱两部分组成。另可提供多种不同的气体控制器，满足不同实验O2、CO2、NO、CO、O3等气体浓度控制的需求。

Ox-100 动物低氧高氧实验系统为动物低氧、高氧实验模型的建立提供合适的氧气环境，可用于模拟生物体内的生理性低氧状态，使体外研究结果更接近于体内的真实水平；或用于模拟生物体处于的特殊低氧/高氧时的病理状态，以便进行相关机理及疾病的研究。可以进行编程式的间歇低氧高氧浓度控制，实现低氧高氧交替实验。

Ox-100 动物低氧高氧实验系统产品特点及参数：

1. 为动物低氧、高氧实验模型的建立提供合适的气体环境

2. 按照设定气体浓度自动配比气体，维持恒定的氧气浓度环境。无需在箱体外混合比例气体，确保实验氧浓度的稳定，节省气源

3. 动态可编程控制的氧浓度实验箱，实现高氧、缺氧间歇交替控制

4. 采用进口透明聚丙烯酸甲酯板（PMMA）材质，坚固耐用

5. 7英寸大屏触摸屏控制，人性化界面，操作简单。

6. 监测参数：温度、湿度、氧气O2浓度。

7. 非色散红外（NDIR）二氧化碳传感器，测量范围：0～5000ppm测量精度：±30ppm

8. 进口电化学氧气O2浓度检测器，测量范围：0-100%vol，测量分辨率：0.01%，线性度好，检测准确、使用寿命长。具有温度补偿机制。

9. 温度检测：进口高精度数字铂电阻温度传感器

10. 氧气浓度变化动态曲线，直观了解氧气浓度变化的过程

11. 氧气浓度自动校准：通过上位机程序对传感器快速校准

12. 湿度传感器和除湿设计，能有效的降低动物实验过程中呼吸产生的水汽对动物的影响。

13. 气体混合及循环机制，保证箱体内气体浓度的均一。

14. 高性能电磁阀，性能稳定，超长寿命＞1000万次

可进行以急性高氧实验、急性缺氧实验、慢性缺氧实验、高氧/低氧交替实验。

应用领域

基因表达研究：有研究表明，基因组中5%的基因表达是受氧气浓度调控的；

肿瘤生物学：迅速增殖的肿瘤内部的细胞，常处于低氧微环境中；

神经生物学：低氧状态下神经细胞的增殖、分化及损伤研究；

睡眠呼吸暂停综合症、心肌缺血缺氧、脑缺血损伤、肺动脉高压、高原反应、肿瘤、眼科疾病、呼吸疾病、造血功能等多种领域的动物建模研究。

相关文献

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[2]Liang Xie, Qinhan Wu, Weiping Hu, Xu Wu, Guiling Xiang, Shengyu Hao, Han Guo, Shanqun Li. “Impact of histaminergic H3 receptor antagonist on hypoglossal nucleus in chronic intermittent hypoxia conditions." [J]. Psychopharmacology.

[3]Li Huang, Tianyou Li, Min Zhou, Mengyan Deng, Lidong Zhang, Long Yi, Jundong Zhu, Xiaohui Zhu, Mantian Mi. “Hypoxia Improves Endurance Performance by Enhancing Short Chain Fatty Acids Production via Gut Microbiota Remodeling." [J]. Front. Microbiol. 12:820691

[4]Yanhong Pei a b, Lifei Huang c, Tong Wang c, Qinhan Yao a, Yanrong Sun a, Yan Zhang a, Xiaomei Yang a, Jiliang Zhai d, Lihua Qin a, Jiajia Xue c, Xing Wang c, Hongquan Zhang a b, Junhao Yan."Bone marrow mesenchymal stem cells loaded into hydrogel/nanofiber composite scaffolds ameliorate ischemic brain injury. materialstoday ADVANCES, Volume 17, March 2023, 100349.

[5]Zhang, C., Sun, Y., Guo, Y. et al. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension. “[J].Cell Death Discov. 9, 98 (2023).

[6]Fang Zhao, Yan Meng, Yue Wang, Siqi Fan, Yu Liu,Xiangfeng Zhang, Chenyang Ran, Hongxin Wang and Meili Lu. "Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway" .[J]. Frontiers in Pharmacology,10.3389/fphar.2022.920977

[7]Chenyu Xu, Jun Xu, Chunfang Zou, Qian Li, Shan Mao, Ying Shi, Yan Tan, Wei Gu, Liang Ye. "Chronic Intermittent Hypoxia Regulates CaMKII-Dependent MAPK Signaling to Promote the Initiation of Abdominal Aortic Aneurysm."  [J]. Hindawi, Oxidative Medicine and Cellular Longevity Volume 2021, Article ID 2502324, 15 pages

[8]Jing Zhang, Jian-Zhong Jiang, Jun Xu, Chen-Yu Xu, Shan Mao, Ying Shi, Wei Gu, Chun-Fang Zou, Yue-Ming Zhao,  Liang Ye. "Identification of Novel Biomarkers for Abdominal Aortic Aneurysm Promoted by Obstructive Sleep Apnea." [J].  Elsevier Inc. This is an open access article under the CC BY-NC-ND license

[9]Zhang Q, Xu L, Bai Y, Chen P, Xing M, Cai F, Wu Y,  Song W. “Intermittent hypoxia-induced enhancement of sociability and working memory associates with CNTNAP2 upregulation." [J]. Front. Mol. Neurosci. 16:1155047.

[10]Chen Zhang, Yue Sun, Yingying Guo, Jingjing Xu, Haiyan Zhao. “JMJD1C promotes smooth muscle cell proliferation by activating glycolysis in pulmonary arterial hypertension." [J]. Cell Death Discovery (2023) 9:98.

[11]Chen-Yu Jiang,Li-Wei Wu,Yi-Wei Liu,Bei Feng, Lin-Cai Ye,Xu Huang,Yang-Yang He,Yi Shen, Yi-Fan Zhu, Xing-Liang Zhou, Dai-Ji Jiang, Hai-Kun Qi, Hao Zhang, and Yi Yan.Identification of ACKR4 as an immune checkpoint in pulmonary arterial hypertension,[J]Frontiers in Immunology,28 June 2023,Volume 14 - 2023, DOI: 10.3389/fimmu.2023.1153573

[12]Haimei Lun, Ruochuan Liu, Qiao Hu, Yaoli Liu, Lisi Wei, Xia Liu, Dan Wu, Shangyong Zhu,Contrast Enhanced Ultrasonography of Kidney in Chronic Intermittent Hypoxia Rat Model,[J]Journal of Ultrasound in Medicine,2022-12-07 ,DOI:10.1002/jum.16147

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