08GSM001GsMTx4
【简单介绍】
【详细说明】
GsMTx4
Selective blocker of mechanosensitive ion channels
压力敏感性离子通道选择性阻断剂
GsMTx4 (GsMTx-4, M-theraphotoxin-Gr1a) has been isolated from the venom of the spider Grammostola rosea. This cationic hydrophobic polypeptide blocks selectively the gating of cation selective channels and mechanosensitive ion channels such as TRPC1 or TRPC6, without having any effect on whole-cell voltage-sensitive currents. This toxin acts by perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. GsMTx4 also demonstrated to active TRPA1 channel at 1µM concentration and to inhibit Piezo1 currents.
技术资料
氨基酸序列:
Gly-Cys2-Leu-Glu-Phe-Trp-Trp-Lys-Cys9-Asn-Pro-Asn-Asp-Asp-Lys-Cys16-Cys17-Arg-Pro-Lys-Leu-Lys-Cys23-Ser-Lys-Leu-Phe-Lys-Leu-Cys30-Asn-Phe-Ser-Phe-NH2
二硫键:Cys2-Cys17, Cys9-Cys23 and Cys16-Cys30
长度 (aa):34
分子式:C185H273N49O45S6
分子量:4095.2 Da
外观:White lyophilized solid
可溶性:water and saline buffer
CAS 号:not available
来源: Synthetic
纯度: > 97 %
产品信息
08GSM001-00050 | 0.05mg | |
08GSM001-00100 | 0.1mg | |
08GSM001-00500 | 0.5mg |
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