12PTB002Biotinyl-ProTx-II（生物素-原毒素-II）

Biotinyl-ProTx-II（生物素-原毒素 II）

ProTx-II (Protoxin-II) is a toxin that was originally isolated from Thrixopelma pruriens (Peruvian green velvet tarantula).ProTx-II inhibits both tetrodotoxin-sensitive and tetrodotoxin-resistant channels. ProTx-II inhibits activation by shifting the voltage-dependence of c hannel activation to more positive potentials. ProTx-II potently inhibits all sodium channel subtypes tested (Na_v1.2/SCN2A, Na_v1.5/SCN5A, Na_v1.7/SCN9A, and Na_v1.8/SCN10A). It is approximay 15-fold more potent on Na_v1.7/SCN9A than on Na_v1.5/SCN5A channels and acts on Ca_v3.1/CACNA1G and interacts more weakly with the related T-Type channel Ca_v3.2/CACNA1H but potently inhibits the L-type calcium channel Ca_v1.2/CACNA1C. ProTx-II also binds to phospholipids. ProTx-II, a selective inhibitor of Na_v1.7 sodium channels, blocks action potential propagation in nociceptors. 

Biotinyl-ProTx-II is a N-ter biotin labeled version of the wild-type  ProTx-II useful for a wide range of experimentations.

Biotinyl-ProTx-II技术资料

氨基酸序列：

Biotin-Tyr-Cys²-Gln-Lys-Trp-Met-Trp-Thr-Cys⁹-Asp-Ser-Glu-Arg-Lys-Cys¹⁵-Cys¹⁶-Glu-Gly-Met-Val-Cys²¹-Arg-Leu-Trp-Cys²⁵-Lys-Lys-Lys-Leu-Trp-OH 

二硫键：Cys²-Cys¹⁶, Cys⁹-Cys²¹ and Cys¹⁵-Cys²⁵ 

长度 (aa)： 30 

分子式： C₁₇₈H₂₅₄N₄₈O₄₃S₉ 

分子量：4052.74 Da 

外观： White lyophilized solid 

可溶性： water and saline buffer 

CAS 号：not available 

来源：Synthetic  

纯度：> 88 %

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