PGLYRP1 Target Cell
| I. Background | |
肽聚糖识别蛋白 1（Peptidoglycan Recognition Protein 1），也被称为 TAG7、PGRP-S， 在昆虫和哺乳动物体内所发现的一种先天性免疫激活蛋白，可介导抗菌作用和先天免疫反 应。PGLYRP1 蛋白在免疫细胞中高度表达，如中性粒细胞、巨噬细胞和嗜酸性粒细胞，并 与多种炎症有关，包括类风湿性关节炎、气道炎症，冠状动脉疾病或者哮喘口腔炎症和癌 症。 | |
| II. Description | |
PGLYRP1 Target Cell 作为 TREM1 Effector Reporter Cell 的靶细胞，很好的模拟了体内 TREM1 的信号转导过程，原理见下图所示。
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| III. Introduction | |
| Expressed gene: | PGLYRP1 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+600 μg/ml Hygromycin B |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Functional(Report Gene) Assay |
| IV. Representative Data | |
Figure 1. Blocking of PGLYRP1 (plus 1ug/ml PGN)induced TREM1 Effector Reporter Cell(C33) Activity by TREM1 Blokcing Ab with PGLYRP1 Target Cell . | |
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