Bcl-6 B细胞淋巴瘤6（鼠单克隆抗体）

Bcl-6 B细胞淋巴瘤6（鼠单克隆抗体）

广州健仑生物科技有限公司

弥漫大B细胞淋巴瘤是NHL中zui常见的类型，几乎占所有病例的1/3。这类淋巴瘤占以前临床上的“侵袭性”或“中高度恶性”淋巴瘤的大多数病例。弥漫大B细胞淋巴瘤正确的诊断需要血液病理学专家根据合适的活检和B细胞免疫表型的证据而得出。近年多个多中心随机对照临床试验研究资料证明，其标准的一线治疗方案应当是利妥昔单抗(Rituximab,R)+CHOP方案，并且通过增加方案的剂量密度，缩短疗程间隙时间，从而获得更好的疗效，如R-CHOP14 方案。

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

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【产品介绍】

细胞定位：细胞核

克隆号：LN22

同型：IgG2b

适用组织：石蜡/冰冻

阳性对照：扁桃体

抗原修复：热修复（EDTA）

抗体孵育时间：30-60min

Bcl-6 B细胞淋巴瘤6（鼠单克隆抗体）

分析
序列测定揭示了酵母基因组中大范围的碱基组成变化。多数酵母染色体由不同程度的、大范围的GC丰富DNA序列和GC缺乏DNA序列镶嵌组成。这种GC含量的变化与染色体的结构、基因的密度以及重组频率有关。GC含量高的区域一般位于染色体臂的中部，这些区域的基因密度较高；GC含量低的区域一般靠近端粒和着丝粒，这些区域内基因数目较为贫乏。Simchen等证实，酵母的遗传重组即双链断裂的相对发生率与染色体的GC丰富区相耦合，而且不同染色体的重组频率有所差别，较小的Ⅰ、Ⅲ、Ⅳ和Ⅸ号染色体的重组频率比整个基因组的平均重组频率高。
酵母基因组另一个明显的特征是含有许多DNA重复序列，其中一部分为*相同的DNA序列，如rDNA与CUP1基因、Ty因子及其衍生的单一LTR序列等。在开放阅读框或者基因的间隔区包含大量的三核苷酸重复，引起了人们的高度重视。因为一部分人类遗传疾病是由三核苷酸重复数目的变化所引起的。还有更多的DNA序列彼此间具有较高的同源性，这些DNA序列被称为遗传丰余（genetic redundancy）。酵母多条染色体末端具有长度超过几十个kb的高度同源区，它们是遗传丰余的主要区域，这些区域至今仍然在发生着频繁的DNA重组过程。遗传丰余的另一种形式是单个基因重复，其中以分散类型zui为典型，另外还有一种较为少见的类型是成簇分布的基因家族。成簇同源区（cluster homology region，简称CHR）是酵母基因组测序揭示的一些位于多条染色体的同源大片段，各片段含有相互对应的多个同源基因，它们的排列顺序与转录方向十分保守，同时还可能存在小片段的插入或缺失。这些特征表明，成簇同源区是介于染色体大片段重复与*分化之间的中间产物，因此是研究基因组进化的良好材料，被称为基因重复的化石。染色体末端重复、单个基因重复与成簇同源区组成了酵母基因组遗传丰余的大致结构。研究表明，遗传丰余中的一组基因往往具有相同或相似的生理功能，因而它们中单个或少数几个基因的突变并不能表现出可以辨别的表型，这对酵母基因的功能研究是很不利的。所以许多酵母遗传学家认为，弄清遗传丰余的真正本质和功能意义，以及发展与此有关的实验方法，是揭示酵母基因组全部基因功能的主要困难和中心问题。

Bcl-6

我司还提供其它进口或国产试剂盒：登革热、疟疾、流感、A链球菌、合胞病毒、腮病毒、乙脑、寨卡、黄热病、基孔肯雅热、克锥虫病、违禁品滥用、肺炎球菌、军团菌、化妆品检测、食品安全检测等试剂盒以及日本生研细菌分型诊断血清、德国SiFin诊断血清、丹麦SSI诊断血清等产品。

想了解更多的产品及服务请扫描下方二维码：

【公司名称】 广州健仑生物科技有限公司
【市场部】    杨永汉

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【腾讯  】 
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室

analysis
Sequencing revealed a wide range of changes in base composition in the yeast genome. Most yeast chromosomes by varying degrees, a wide range of GC-rich DNA sequence and GC lack of DNA sequence mosaic composition. This change in GC content is related to the structure of the chromosome, the density of the gene, and the frequency of recombination. GC-rich areas are generally located in the middle of the chromosome arm, the gene density of these areas is higher; GC low-lying areas are generally close to the omere and centromere, the number of genes in these areas is relatively poor. Simchen et al. Confirmed that the relative frequency of yeast genetic recombination, ie, double-strand breaks, is coupled with the GC rich region of chromosomes, and the recombination frequency differs between different chromosomes. The smaller recombination frequencies of chromosomes I, III, IV, and IX Higher than the average recombination frequency of the entire genome.
Another obvious feature of the yeast genome is that it contains many DNA repeats, some of which are identical DNA sequences, such as rDNA and CUP1 genes, Ty factors and their derived single LTR sequences. In the open reading frame or gene spacer contains a large number of trinucleotide repeats, aroused people's attention. Because part of the human genetic disease is caused by changes in the number of trinucleotide repeats. There are many more DNA sequences that have higher homology to each other, and these DNA sequences are called genetic redundancy. At the ends of yeast chromosomes, there are highly homologous regions of more than several dozen kb in length, which are the major areas of genetic redundancy that are still undergoing frequent DNA recombination processes to this day. Another form of genetic redundancy is a single gene duplication, of which the most typical type of dispersion, in addition there is a less common type is a cluster of gene clusters. Clustered homology regions (CHRs) are homologous large fragments of multiple chromosomes revealed by yeast genome sequencing. Each fragment contains multiple homologous genes corresponding to each other, and their arrangement order and transcription direction are very close Conservative, while there may be small insertions or deletions. These features indicate that clustered homology regions are intermediate products between the repetition and complete differentiation of large chromosome segments and are therefore good materials for studying the evolution of the genome and are known as gene duplication fossils. Chromosome end repeats, single gene duplication and clustered homologous regions constitute the general structure of yeast genetic redundancy. Studies have shown that a group of genes in genetic redundancy tend to have the same or similar physiological functions, so that mutations in one or a few of them do not show discernable phenotypes. The functional study of yeast genes is very Adverse. Therefore, many yeast genetics believe that to understand the true nature of genetic redundancy and functional significance, as well as the development of experimental methods associated with this, is to reveal the major problems and central issues of the whole genome function of the yeast genome.