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【公司名称】 广州健仑生物科技有限公司
【市场部】 欧
【】
【腾讯 】
【公司地址】 广州清华科技园创新基地番禺石楼镇创启路63号二期2幢101-103室
RNA是以DNA的一条链为模板,以碱基互补配对原则,转录而形成
的一条单链,主要功能是实现遗传信息在蛋白质上的表达,是遗
传信息向表型转化过程中的桥梁。在此过程中,转运RNA
(Transfer RNA,tRNA)是携带与三联体密码子对应的氨基酸残基
与正在进行翻译的mRNA结合,而后核糖体RNA(Ribosomal
RNA,rRNA)将各个氨基酸残基通过肽键连接成肽链进而构成蛋白
质分子。RNA由核糖核苷酸经磷酯键缩合而成长链状分子。一个核
糖核苷酸分子由磷酸,核糖和碱基构成。RNA的碱基主要有4种,
即A腺嘌呤 ,G鸟嘌呤 ,C胞嘧啶 ,U尿嘧啶 。其中,U尿嘧
啶取代了DNA中的T胸腺嘧啶而成为RNA的特征碱基。mRNA1958年
,克里克提出RNA是遗传信息的中间载体这一假设。提出该假设的
部分依据是:DNA位于真核细胞的细胞核,而蛋白质分子是在细胞
质中被合成的。这一事实提示,存在某种物质携带并传递遗传信
息。克里克注意到,核糖体含有RNA并提出核糖体RNA(rRNA)是
遗传信息的传递载体。由于rRNA是核糖体的组成部分,不可能离
开核糖体。克里克假设每个核糖体以其自身的rRNA能够一遍又一
遍的重复生产同一种蛋白质。Francois Jacob及同事提出了另一
种假设,认为是非特异性的核糖体翻译一种叫做信使的不稳定的
RNA。信使是独立的RNA分子,可将遗传信息从基因传递至核糖体
。1961年Jacob与Sydney Brenner和Matthew Meselson一起发
表了关于信使假说的证据。实验发现,T2噬菌体感染大肠杆菌后
,其RNA分子与宿主核糖体结合,合成噬菌体蛋白。表明核糖体合
成的蛋白种类取决于与之结合的mRNA而非rRNA。其他研究者亦鉴
定出一种更好的信使——一组与核糖体瞬时结合的不稳定RNA。与
rRNA不同,mRNA碱基的组成与T2噬菌体DNA相似,支持了mRNA而
非rRNA是信息分子的假设。现在我们已经证实,mRNA功能是在蛋
白分子合成过程中,作为“信使”分子,将基因组DNA的遗传信息
(即碱基排列顺序)传递至核糖体,使核糖体能够以其碱基排列
顺序掺入互补配对的tRNA分子,进而合成正确的肽链,实现遗传
信息向蛋白质分子
RNA is a strand of DNA as a template to complement the principle of base pairing, transcription and formation
Of a single chain, the main function is to achieve the expression of genetic information on the protein is left
Transmission of information to the phenotype of the bridge during the conversion process. In the process, RNA is transported
(Transfer RNA, tRNA) is an amino acid residue that corresponds to the triplet codon
Binds to the mRNA that is undergoing translation, and then ribosomal RNA (Ribosomal
RNA, rRNA) The individual amino acid residues are joined by peptide bonds to form peptide
Qualitative molecules. RNA from the ribonucleotide by phosphorus ester bond condensation and growth of chain molecules. A nuclear
Sugar nucleotide molecules consist of phosphoric acid, ribose and bases. There are four types of RNA bases,
Namely A adenine, G guanine, C cytosine, U uracil. Among them, U uracil
Pyridine replaces T-thymine in DNA and becomes the characteristic base of RNA. mRNA 1958
, Crick put forward the hypothesis that RNA is an intermediate vector for genetic information. Put forward the hypothesis
Partly based on the fact that DNA is located in the nucleus of a eukaryotic cell and that the protein molecule is in a cell
The substance is synthesized. This fact suggests that there is something that carries and transmits genetic letters
interest. Crick notes that ribosomes contain RNA and suggest that ribosomal RNA (rRNA) is
Genetic information delivery carrier. Since rRNA is an integral part of the ribosome, it is impossible to leave
Open ribosome. Crick assumes that each ribosome can be able to iterate over its own rRNA
Repeat the same production of the same protein. Francois Jacob and colleagues put forward another
The hypothesis is that the nonspecific ribosome translates a form of instability called messenger
RNA. Couriers are independent RNA molecules that transmit genetic information from the gene to the ribosome
. 1961 Jacob and Sydney Brenner and Matthew Meselson together
Table evidence of the messenger hypothesis. The experiment found that T2 phage infection after E. coli
, Its RNA molecules and the host ribosome binding, synthesis of phage protein. That ribosomes together
The type of protein that is formed depends on the mRNA it binds to rather than on rRNA. Other researchers also learn
Set a better messenger - a group of unstable RNAs that bind to ribosomes transiently. versus
Different rRNA mRNA base composition and T2 phage DNA similar support mRNA
Non-rRNA is a hypothetical information molecule. Now we have confirmed that mRNA function is in the egg
The process of white molecule synthesis, as a "messenger" molecule, will be genomic DNA genetic information
(Ie, the order of the bases) to the ribosome so that the ribosomes can be arranged in their bases
Sequential incorporation of complementary paired tRNA molecules, and then synthesize the correct peptide chain, to achieve genetic
Information to protein molecules