DKK-1 ELISA Kit (BI-20413)
背景简介:
DKK-1和Sclerostins是wnt信号通路的有效的抑制剂,且在成骨细胞的分化过程中发挥重要作用。研究表明,骨形成减少、多发性骨髓瘤或由乳腺癌、前列腺癌、肺癌或关节炎引起的骨转移,都可导致DKK-1水平升高。
产品优势:
1)当日即可检测
2)直接测定,不许样品稀释。
3)样本需求量少,只需:20ul
4)标准品范围广
5)充分证实可用于人血清样本检测
6)6个标准品+1个对照(均为血清基质)
7)操作流程简单
试剂盒特点:
1)检测方法:夹心ELISA,HRP/TMB显色系统
2)样本类型:血清
3)样品量:20ul/test
4)标准品范围:0-160 pmol/L
5)检测灵敏度:1.7pmol/L
6)孵育条件:2h/1h/30min
参考文献:
1. Elevated Serum Dickopff-1 Levels Increase Risk of Hip and Vertebral Fracture in Older Caucasian Women. Aarthi Arasu,et al. Endocr. Rev., Jun 2013; 34: SAT-224.
2. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis. Diederik P C de Rooy,et al. Ann Rheum Dis, May 2013; 72: 769 - 775.
3. High dickkopf-1 levels in sera and leukocytes from children with 21-hydroxylase deficiency on chronic glucocorticoid treatment. Giacomina Brunetti,et al. Am J Physiol Endocrinol Metab, Mar 2013; 304: E546 - E554.
4. The Effect of Zoledronic Acid on Serum Dickkopf-1, Osteoprotegerin, and RANKL
in Patients with Paget's Disease of Bone. S A Polyzos, et al. Horm Metab Res, Aug 2009
5. Circulating Dickkopf-1 and Radiological Progression in Patients with Early Rheumatoid Arthritis Treated with Etanercept. Patrick Garnero,et al. J Rheumatol, Oct 2008
更多产品信息,请垂询Biomedica 中国区总代理北京博蕾德生物科技有限公司