美国flexcell FX-5000C细胞压力刺激加载文献，细胞压缩力加载文献

COMPRESSION SYSTEM AND COMPRESSION PLATES

Bougault C, Aubert-Foucher E, Paumier A, Perrier-Groult E, Huot L, Hot D, Duterque-Coquillaud M, Mallein-Gerin F. Dynamic compression of chondrocyte-agarose constructs reveals new candidate mechanosensitive genes. PLoS One 7(5):e36964, 2012.  

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Bougault C, Paumier A, Aubert-Foucher E, Mallein-Gerin F. Molecular analysis of chondrocytes cultured in agarose in response to dynamic compression. BMC Biotechnol 8:71, 2008.

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Chen X, Guo J, Yuan Y, Sun Z, Chen B, Tong X, Zhang L, Shen C, Zou J.Cyclic compression stimulates osteoblast differentiation via activation of the Wnt/β-catenin signaling pathway. Molecular Medicine Reports 15(5):2890-2896, 2017.

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Damaraju S, Matyas JR, Rancourt DE, Duncan NA. The effect of mechanical stimulation on mineralization in differentiating osteoblasts in collagen-I scaffolds. Tissue Eng Part A 20(23-24):3142-3153, 2014.  

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Damaraju S, Matyas JR, Rancourt DE, Duncan NA. The role of gap junctions and mechanical loading on mineral formation in a collagen-I scaffold seeded with osteoprogenitor cells. Tissue Eng Part A 21(9-10):172032, 2015.  

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Fermor B, Haribabu B, Weinberg JB, Pisetsky, Guilak F. Mechanical stress and nitric oxide influence leukotriene production in cartilage. Biochemical and Biophysical Research Communications 285:806–810, 2001.

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Fermor B, Weinberg JB, Pisetsky DS, Guilak F. The influence of oxygen tension on the induction of the nitric oxide and prostaglandin E2 by mechanical stress in articular cartilage. Osteoarthritis Cartilage 13:935941, 2005.

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Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Banes AJ, Guilak F. The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. J Orthop Res 9(4):729-737, 2001.

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Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Fink C, Guilak F. Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. Osteoarthritis Cartilage 10:792–798, 2002.

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Fink C, Fermor B, Weinberg JB, Pisetsky DS, Misukonis MA, Guilak F. The effect of dynamic mechanical compression on nitric oxide production in the meniscus. Osteoarthritis Cartilage 9(5):481-487, 2001.

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Fox DB, Cook JL, Kuroki K, Cockrell M. Effects of dynamic compressive load on collagen-based scaffolds seeded with fibroblast-like synoviocytes. Tissue Eng 12(6):1527-1537, 2006.

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Glaeser JD, Salehi K, Kanim LE, NaPier Z, Kropf MA, Cuellar J, Sheyn D, Bae HW. Treatment with the NFkB inhibitor reduces overloading-induced MMP expression in human nucleus pulposus cells. The Spine Journal 17(10):S127, 2017.

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Gosset M, Berenbaum F, Levy A, Pigenet A, Thirion S, Saffar JL, Jacques C. Prostaglandin E2 synthesis in cartilage explants under compression: mPGES-1 is a mechanosensitive gene. Arthritis Research & Therapy 8:R135, 2006.

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Graff RD, Lazarowski ER, Banes AJ, Lee GM. ATP release by mechanically loaded porcine chondrons in pellet culture. Arthritis Rheum 43(7):1571-1579, 2000.

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Hamid T, Xu Y, Ismahil MA, Li Q, Jones SP, Bhatnagar A, Bolli R, Prabhu SD. TNF receptor signaling inhibits cardiomyogenic differentiation of cardiac stem cells and promotes a neuroadrenergic-like fate. Am J Physiol Heart Circ Physiol 311(5):H1189-H1201, 2016.  

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Hara M, Nakashima M, Fujii T, Uehara K, Yokono C, Hashizume R, Nomura Y. Construction of collagen gel scaffolds for mechanical stress analysis. Biosci Biotechnol Biochem 78(3):458-61, 2014. doi: 10.1080/09168451.2014.882749.

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Hazenbiller O, Duncan NA, Krawetz RJ. Reduction of pluripotent gene expression in murine embryonic stem cells exposed to mechanical loading or Cyclo RGD peptide. BMC Cell Biol 18(1):32, 2017. doi: 10.1186/s12860-017-0148-6.

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Hennerbichler A, Fermor B, Hennerbichler, Weinberg JB, Guilak F. Regional differences in prostaglandin E2 and nitric oxide production in the knee meniscus in response to dynamic compression. Biochemical and Biophysical Research Communications 358:1047–1053, 2007.

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Huang D, Liu YP, Huang YJ, Xie YF, Shen KH, Zhang DW, Mou Y. Mechanical compression up-regulates MMP9 through SMAD3 but not SMAD2 modulation in hypertrophic scar fibroblasts. Connect Tissue Res 55(5-6):391-6, 2014. doi: 10.3109/03008207.2014.959118.

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Klymenko Y, Wates RB, Weiss-Bika H, Lombard R,Liu Y, Campbell L, Kim O, Wagner D, Ravosa MJ, Stack MS. Modeling the effect of ascites-induced compression on ovarian cancer multicellular aggregates. Dis Model Mech.2018 Sep 25; 11 (9).

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Kuroki K, Cook JL, Stoker AM, Turnquist SE, Kreeger JM, Tomlinson JL. Characterizing osteochondrosis in the dog: potential roles for matrix metalloproteinases and mechanical load in pathogenesis and disease progression. Osteoarthritis Cartilage 13:225-234, 2005.  

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Lee CY, Hsu HC, Zhang X, Wang DY, Luo ZP. Cyclic compression and tension regulate differently the metabolism of chondrocytes. J Musculoskeletal Res 9(2):59-64, 2005.

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Li D, Lu Z, Xu Z, Ji J, Zheng Z, Lin S, Yan T. Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress. Biosci Rep 36(4), 2016. pii: e00355.  

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Li X, Dong J, Liu C, Wang X, An M, Chen W. Contributions of intermittent cyclic compression to proteoglycans synthesis and mechanical properties of knee articular cartilaginous tissue formed in vitro. Biomedical Engineering and Informatics (BMEI), 2010 3rd International Conference 4:1655-1658, 2010.  

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Maxson S, Orr D, Burg K. Bioreactors for tissue engineering. Tissue Eng 179-197, 2011.

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Miki Y, Teramura T, Tomiyama T, Onodera Y, Matsuoka T, Fukuda K, Hamanishi C. Hyaluronan reversed proteoglycan synthesis inhibited by mechanical stress: possible involvement of antioxidant effect. Inflamm Res 59(6):471-477, 2010.

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Nettelhoff L, Grimm S, Jacobs C, Walter C, Pabst AM, Goldschmitt J, Wehrbein H. Influence of mechanical compression on human periodontal ligament fibroblasts and osteoblasts. Clin Oral Investig 20(3):621-9, 2016. doi: 10.1007/s00784-015-1542-0. Epub 2015 Aug 6.
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Pecchi E, Priam S, Gosset M, Pigenet A, Sudre L, Laiguillon MC, Berenbaum F, Houard X. Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain. Arthritis Res Ther 16(1):R16, 2014. doi: 10.1186/ar4443.

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Piscoya JL, Fermor B, Kraus VB, Stabler TV, Guilak F. The influence of mechanical compression on the induction of osteoarthritis-related biomarkers in articular cartilage explants. Osteoarthritis Cartilage 13:10921099, 2005.

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Saminathan A, Sriram G, Vinoth JK, Cao T, Meikle MC. Engineering the periodontal ligament in hyaluronan-gelatin-type I collagen constructs: upregulation of apoptosis and alterations in gene expression by cyclic compressive strain. Tissue Eng Part A 21(3-4):518-29, 2015.  

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Sanchez C, Gabay O, Salvat C, Henrotin YE, Berenbaum F. Mechanical loading highly increases IL-6 production and decreases OPG expression by osteoblasts. Osteoarthritis Cartilage 17(4):473-481, 2009.  

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Sanchez C, Pesesse L, Gabay O, Delcour JP, Msika P, Baudouin C, Henrotin YE. Regulation of subchondral bone osteoblast metabolism by cyclic compression. Arthritis Rheum 64(4):1193-203. 2012.  

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Sharma R, Vinjamaram S, Shah VA, Gupta SK, Chalam KV. The effect of elevated atmospheric pressure on the survival of retinal ganglion cells using Flexcell biopress system. Invest Ophthalmol Vis Sci 44:E-Abstract 152, 2003.

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Shin SJ, Fermor B, Weinberg JB, Pisetsky DS, Guilak F. Regulation of matrix turnover in meniscal explants: role of mechanical stress, interleukin-1, and nitric oxide. J Appl Physiol 95(1):308-313, 2003.

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Tomiyama T, Fukuda K, Yamazaki K, Hashimoto K, Ueda H, Mori S, Hamanishi C. Cyclic compression loaded on cartilage explants enhances the production of reactive oxygen species. J Rheumatol 34(3):556-562, 2007.  

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Uehara K, Hara M, Matsuo T, Namiki G, Watanabe M, Nomura Y. Hyaluronic acid secretion by synoviocytes alters under cyclic compressive load in contracted collagen gels. Cytotechnology 67(1):19-26, 2015. doi: 10.1007/s10616-013-9669-9.

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Upton ML, Chen J, Guilak F, Setton LA. Differential effects of static and dynamic compression on meniscal cell gene expression. J Orthop Res 21(6):963-969, 2003.

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Werkmeister E, de Isla N, Netter P, Stoltz JF, Dumas D. Collagenous extracellular matrix of cartilage submitted to mechanical forces studied by second harmonic generation microscopy. Photochem Photobiol 86(2):302-310, 2010.  

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Xu HG, Zhang W, Zheng Q, Yu YF, Deng LF, Wang H, Liu P, Zhang M. Investigating conversion of endplate chondrocytes induced by intermittent cyclic mechanical unconfined compression in three-dimensional cultures. European Journal of Histochemistry 58:2415, 2014.

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Zhou Q, Yu BH, Liu WC, Wang ZL. BM-MSCs and Bio-Oss complexes enhanced new bone formation during maxillary sinus floor augmentation by promoting differentiation of BM-MSCs. In Vitro Cell Dev Biol Anim 2016 Jun 1.

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APPLICATION OF COMPRESSION SYSTEM

Ackermann P, Schizas N, Bring D, Li J, Andersson T, Fahlgren A, Aspenberg P. Compression therapy promotes tissue repair and biomechanical properties during immobilization. J Bone Joint Surg Br 94B (Supp XXXVII) 89, 2012.

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美国flexcell FX-5000C细胞压力刺激加载培养系统介绍：

为组织、三维细胞培养物提供周期性或静态压力加载和实时观察

适用样品：细胞或组织
样品模式：3D水凝胶包埋细胞或组织
压力模式：真空顶挤压力培养板的基底硅胶膜使样品受压
实时观察：StagePress显微附属设备可在显微镜下观察压力作用下反应
方便对照：可使同一块培养板力的一部分细胞受力，一部分不受力
多同压缩条件作用对照：可同时运行多个不同压力大小、不同频率
不同加载周期程序，方便对比；
软件精准调控：对压缩加载周期、压力大小、频率、波形智能调控
压力范围：0.1-14磅
压缩频率：0.01- 5 Hz
细胞量大便于后期分析：每个压力传导仪支持4块6孔压力板(1*104 -
1*105悬浮细胞/ml水凝胶），系统同时兼容4个FlexLink压力传导仪，
独立操作四个不同的实验程序 。
支持任何波形种类：可以更好地控制超低或超高压力下的波形