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Biologically active Camellia oleifera protein
nanoparticles for improving the tumor
microenvironment and drug delivery†
Xiaoping Qian,a Tinghui Shen,a Xiaoke Zhang,a Chongzhi Wang,a Weibo Cai,b
Rongshi Chenga and Xiqun Jiang
*a
It is important for antitumor drugs to accumulate at the tumor site and penetrate deeply to play a role in
treatment. However, it is diffiffifficult for the drugs to reach the destination on account of the complex tumor
microenvironment such as elevated tumor interstitial flfluid pressure (IFP) and solid stress. Here, we report
a type of nanocarrier composed entirely of Camellia oleifera protein (COP), which could lower tumor IFP
and solid stress. Its physicochemical properties, cellular uptake, in vitro cytotoxicity and tumor perfusion,
biodistribution, and in vivo antitumor effiffifficiency were evaluated. It was found that COP NPs had good cel
lular uptake ability and cytocompatibility. When loading doxorubicin, COP NPs showed an in vitro con
centration-dependent cytotoxicity. Importantly, the tumor IFP and solid stress were greatly reduced after
injecting COP NPs into tumor-bearing mice, leading to more drug accumulating in the tumor and a
longer survival time for tumor-bearing mice. Therefore, our study provided a new strategy to improve the
tumor microenvironment and to achieve better antitumor effiffifficiency.