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目录:杭州斯达特生物科技有限公司>>抗体/抗原>>流式抗体>> S0B5504Alexa Fluor? 647 Mouse Anti-Human CD123 Antibody (S-R442)

Alexa Fluor? 647 Mouse Anti-Human CD123 Antibody (S-R442)
  • Alexa Fluor? 647 Mouse Anti-Human CD123 Antibody (S-R442)
参考价 1000
具体成交价以合同协议为准
参考价 1000
具体成交价以合同协议为准
  • 品牌 Starter/斯达特
  • 型号 S0B5504
  • 厂商性质 生产商
  • 所在地 杭州市
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更新时间:2025-07-13 12:04:35浏览次数:43评价

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Alexa Fluor? 647 Mouse Anti-Human CD123 Antibody (S-R442)

CD123, also known as the alpha chain of the interleukin-3 receptor (IL-3Rα), is a membrane-bound protein that plays a crucial role in immune regulation and hematopoiesis. It is overexpressed in various hematologic malignancies, including acute myeloid leukemia (AML), blastic plasmacytoid dendritic cell neoplasm (BPDCN), acute lymphoblastic leukemia (ALL), hairy cell leukemia, and systemic mastocytosis. The CD123 protein consists of three extracellular domains, a single-pass transmembrane domain, and a short intracellular region. It is involved in the growth, proliferation, survival, and differentiation of hematopoietic cells. CD123 is particularly significant as a biomarker for targeted therapy in these diseases, with various pharmacologic strategies and agents under investigation or already approved for clinical use. For instance, Tagraxofusp, an anti-CD123 antibody conjugated to diphtheria toxin, has been approved for use in patients with BPDCN.

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