商品信息

产品英文名称	Human IL-17A Protein
产品中文名称	17A（IL-17A）
别名	interleukin 17A, CTLA-8, IL17, IL17A

商品属性

表达宿主	大肠杆菌
种属	人
序列	氨基酸序列来源于：人IL-17A (Ile20-Ala155) (Q16552) 表达的蛋白片段。
活性	Testing in progress.
蛋白长度	重组人IL-17A由136个氨基酸组成，预测分子量为15.7 KD。
纯度	> 98% ，使用SDS-PAGE检测
特点&优势	通过LAL法测定，每微克蛋白里内毒素含量<0.1>
产品形式	冻干粉，冻干缓冲液为无菌的20 mM Tris，50 mM NaCl，pH 8.0。
基因ID	3605
蛋白序列链接	/uniprotkb/Q16552/entry#sequences
使用中注意事项	开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。
保存建议	本产品为冻干粉形式，建议：将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HSA或者BSA），并酌情分装保存，避免反复冻融。
运输条件	冰袋运输（蓝冰）
警告	本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为，我们不承担任何责任。

附加信息

背景

Interleukin-17A (IL-17A), also known as CTLA-8, belongs to the IL-17 cytokine family. IL-17A is expressed in memory Th17 cells and is a product of memory CD4+T cells. In addition to Th17 cells, IL-17A can also be produced by various immune cells, including CD8+T cells γδ T cells, natural killer T (NKT) cells, monocytes, and neutrophils. IL-17A plays a crucial role in the host's defense mechanisms against many bacterial and fungal pathogens, as well as in allergic and autoimmune responses. IL-17A plays a role in viral infection by promoting neutrophil inflammation. IL-17A is a homodimeric cytokine with similar biological activity to IL-17F. IL-17A and IL-17RA have high affinity binding, and IL-17RA is essential for the biological activity of IL-17A. IL-17A cannot bind to T cells, B cells, and myeloid cells lacking IL-17RA. IL-17A is associated with various autoimmune diseases, such as rheumatoid arthritis, multiple sclerosis, inflammatory bowel disease, asthma, and psoriasis. IL-17A also plays a pathogenic role in cancer. During tumor development, IL-17A recruits bone marrow-derived suppressor cells (MDSCs) to suppress anti-tumor immunity. IL-17A also promotes tumor growth in vivo by inducing IL-6.

图片及说明