商品信息

产品英文名称	Human IGF1 Protein
产品中文名称	样生长因子1（IGFI）
别名	Long R3 IGF-I; Insulin-like growth factor I; MGF; Somatomedin-C; IBP1

商品属性

标签	无标签
表达宿主	大肠杆菌
种属	人
序列	氨基酸序列来源于：样生长因子1（IGFI) (P05019-1) (Gly49-Ala118) 表达的蛋白片段。
活性	通过其诱导MCF-7细胞增殖的能力来测定。该效应的ED50为76.41 ng/mL。
蛋白长度	样生长因子1（IGFI） 由71个氨基酸组成，预测分子量为7.8 KD。
纯度	> 99% ，使用SDS-PAGE检测
特点&优势	通过LAL法测定，每微克蛋白里内毒素含量<1.0>
产品形式	冻干粉，冻干缓冲液为无菌的20 mM Tris，150 mM NaCl，pH 7.4。
基因ID	3479
蛋白序列链接	/uniprotkb/P05019/entry#P05019-1
使用中注意事项	开盖使用前，请先离心。本产品为冻干粉，推荐用该产品配套的Reconstitution Buffer进行复溶，且浓度不低于100 µg/mL。客户可根据后续的实验需求，进行进一步的稀释。
保存建议	本产品为冻干粉形式，建议：将冻干粉产品保存于-20℃以下的干燥环境中。本产品溶解之后，可在4℃保存2-7天，长期使用请置于-20℃以下。为长期保存，推荐添加载体蛋白（0.1% HAS/BSA或13%FBS），并酌情分装保存，避免反复冻融。
运输条件	冰袋运输（蓝冰）
警告	本文列出的产品仅供研究使用，不适用于人类或临床诊断。我们产品所推荐应用，不是建议使用我们的产品去违反任何或许可证。对于使用本产品可能发生的侵权或其他违规行为，我们不承担任何责任。

附加信息

背景

IGF I, also known as Mechano Growth Factor, somatomedin-C, IGF-I, and IGF1, is a secreted protein that belongs to the insulin family. The insulin family, comprised of insulin, relaxin, insulin-like growth factors I and II ( IGF-I and IGF-II ), and possibly the beta-subunit of 7S nerve growth factor, represents a group of structurally related polypeptides whose biological functions have diverged. The IGFs, or somatomedins, constitute a class of polypeptides that have a key role in pre-adolescent mammalian growth. IGF-I expression is regulated by GH and mediates postnatal growth, while IGF-II appears to be induced by placental lactogen during prenatal development. IGF1 / IGF-I may be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. IGF1 / IGF-I stimulates glucose transport in rat bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also about enhancing glucose uptake. Defects in IGF1 / IGF-I are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) which is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness, and mental retardation.

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