产品货号：BD-PB3382

别名：Protein lin-28 homolog A, Lin-28A, lin28a, lin28

产品名称：(DANRE) lin28a Rabbit Polyclonal Antibody (Center)

类别：抗原抗体

推荐应用：WB

反应种属：Zebrafish

Human Swissprot No.Q803L0

特异性：This DANRE lin28a antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 85-119 amino acids from the Central region of DANRE lin28a.

稀释度：WB 1:2000

预测分子量：22kDa

(DANRE) lin28a Rabbit Polyclonal Antibody (Center)同种型：Rabbit Ig

背景介绍：Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting an uridylyltransferase, leading to the terminal uridylation of pre- let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation (By similarity).

细胞定位：Cytoplasm {ECO:0000250|UniProtKB:Q8K3Y3}. Rough endoplasmic reticulum {ECO:0000250|UniProtKB:Q8K3Y3}. Cytoplasm, P-body {ECO:0000250|UniProtKB:Q9H9Z2}. Cytoplasm, Stress granule {ECO:0000250|UniProtKB:Q8K3Y3}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q8K3Y3}. Note=Predominantly cytoplasmic. In the cytoplasm, localizes to peri-endoplasmic reticulum regions and may be bound to the cytosolic surface of rough endoplasmic reticulum (ER) on which ER-associated mRNAs are translated. Shuttle from the nucleus to the cytoplasm requires RNA-binding. {ECO:0000250|UniProtKB:Q8K3Y3}

上海博盛龙生物科技有限公司专业从事生物实验耗材的研发生产，致力于为客户提供高品质、低成本的优质实验耗材。

博盛龙拥有十万级无尘GMP车间1000平方米，仓储间1500平方米，使用优良工艺及表面处理技术，严格质量保证。目前主营产品有：广口试剂瓶、窄口试剂瓶、试剂瓶配套彩盖、可立保存管、保存管配套彩盖、方形血清瓶和PCR八联排管等。