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产品型号27752-1

品牌BPS Bioscience

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更新时间：2023-11-11 09:51:51浏览次数：130次

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Inhibitors / Activators

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产品简介

●Purchase●DescriptionICG1isasmallmoleculeinhibitorthattargetsWnt/β-cateninpathway

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Description

ICG 1 is a small molecule inhibitor that targets Wnt/β-catenin pathway. It inhibits TCF/β-catenin mediated transcription by competing with β-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 µM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.

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Synonyms

(6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide

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