UPF 1069 返回列表页

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产品型号

品牌BPS Bioscience

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产品简介

保存条件：Roomtemp

详情介绍

保存条件：
Room temp. (continental US) or gel packs
保质期：
Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
英文名：
UPF 1069
数量：
1
供应商：
BPS Bioscience Inc.
CAS号：
/
规格：
10 mg

UPF 1069, a derivative of isoquinolinone, is a potent and selective inhibitor of poly-(ADP-ribose) polymerase 2 (PARP-2) that is capable of reducing PAR formation both in recombinant enzyme preparations and in nuclear extracts from PARP-1-/- fibroblasts. Although its inhibition towards PARP-2 is most selective among other PARP-2 inhibitors, UPF 1069 also inhibits PARP-1 with a lesser potency . Having been used to investigate the role of PARP-1 and PARP-2 in post-ischaemic brain damage, UPF 1069 enhances oxygen-glucose deprivation (OGD) injury in hippocampal slices.

温馨提示：不可用于临床治疗。