BPS Bioscience Inc.
中级会员 | 第3年

当前位置:BPS Bioscience Inc.>>试剂>>药物筛选>> Romidepsin (FK228, depsipeptide)

Romidepsin (FK228, depsipeptide)

参  考  价面议
具体成交价以合同协议为准

产品型号

品       牌BPS Bioscience

厂商性质生产商

所  在  地

更新时间:2023-12-19 23:34:26浏览次数:189次

联系我时,请告知来自 化工仪器网
同类优质产品更多>
保存条件:Roomtemp
  • 保存条件:

    Room temp. (continental US) or gel packs

  • 保质期:

    Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

  • 英文名:

    Romidepsin (FK228, depsipeptide)

  • 数量:

    1

  • 供应商:

    BPS Bioscience Inc.

  • CAS号:

    /

  • 规格:

    1 mg

Romidepsin, also known as FK228 or depsipeptide, is a potent and selective inhibitor of HDAC1 and HDAC2 , which are associated with the regulation of re-expression of silenced tumor suppressor genes. It was the first HDAC inhibitor to manifest anti-tumor activity and originally isolated from a rod-shaped Gram-negative bacterium, Chromobacterium violaceum, found in a Japanese soil sample. Romidepsin exhibits a stronger inhibition towards HDAC1 and HDAC2 enzymes (class I), removing acetyl groups from the lysine residues of N-terminal histone tails and maintaining a more open and transcriptionally active chromatin state, than HDAC4 and HDAC6 enzymes (class II). Besides HDAC inhibition, romidepsin is also able to induce cell cycle arrest, cellular differentiation, apoptosis and alteration of gene expression in adult malignancies.
温馨提示:不可用于临床治疗。

会员登录

×

请输入账号

请输入密码

=

请输验证码

收藏该商铺

X
该信息已收藏!
标签:
保存成功

(空格分隔,最多3个,单个标签最多10个字符)

常用:

提示

X
您的留言已提交成功!我们将在第一时间回复您~
拨打电话
在线留言