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NLG919

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品       牌BPS Bioscience

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更新时间:2023-12-19 23:31:29浏览次数:195次

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保存条件:-80°C(dryice)保质期:Storeassuppliedatorbelow-20°Cforupto3years
  • 保存条件:

    -80°C (dry ice)

  • 保质期:

    Store as supplied at or below -20°C for up to 3 years. Stable in DMSO at -80°C for up to 6 months.

  • 英文名:

    NLG919

  • 数量:

    1

  • 供应商:

    BPS Bioscience Inc.

  • CAS号:

    /

  • 规格:

    10 mg

NLG919 is an orally available potent inhibitor of the indoleamine-2,3-dioxygenase (IDO1) pathway, a crucial pathway involved in allergic inflammation that mediatesimmunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2,mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated forthe treatment of immunosuppression associated with cancer.
温馨提示:不可用于临床治疗。

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