MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MMAF-d₈ (hydrochloride)

产品活性：MMAF-d₈ (hydrochloride)e是MMAF hydrochloride的氘代形式。

研究领域：Cytoskeleton  |  Cell Cycle/DNA Damage  |  Antibody-drug Conjugate/ADC Related

作用靶点：Microtubule/Tubulin  |  ADC Cytotoxin

In Vitro: MMAF shows in vitro cytotoxicity against a panel of cell lines. The IC₅₀ values for Karpas 299, H3396, 786-O and Caki-1 are 119, 105, 257, and 200 nM, respectively. Targeted MMAF is much more potent than the free drug, and that cAC10 conjugates of MMAF display pronounced activities. On a molar basis, the cAC10-L1-MMAF₄ is an average of over 2200-fold more potent than free MMAF and is active on all the CD30-positive cell lines tested.

In Vivo: The maximum tolerated dose in mice of MMAF (>16 mg/kg) is much higher than MMAE (1 mg/kg). cAC10-L1-MMAF₄ has an MTD of 50 mg/kg in mice and 15 mg/kg in rats. The corresponding cAC10-L4-MMAF₄ ADC was much less toxic, having MTDs in mice and rats of >150 mg/ kg and 90 mg/kg in rats, respectively.

相关产品：Tirbanibulin dihydrochloride  |  Tubulysin IM-3  |  AMXI-5001 hydrochloride  |  Tubulin polymerization-IN-21  |  Dolastatin 10  |  (+)-CBI-CDPI1  |  SB-216  |  MAP4343  |  Duocarmycin GA  |  Tubulin polymerization-IN-8  |  Tubulysin IM-1  |  Maytansinoid B  |  Colchicine-d₃  |  2-Methoxyestradiol-¹³C,d₃  |  Taltobulin  |  Albendazole  |  Duocarmycin DM free base  |  Dideoxy-amanitin  |  Tilavonemab  |  DM4-d₆  |  Camptothecin  |  EGFR-IN-57  |  Epothilone B  |  Epothilone A  |  Maytansinol  |  Maytansinoid DM4  |  Docetaxel-d₉  |  N-Me-L-Ala-maytansinol  |  Duocarmycin A  |  Verubulin hydrochloride

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种*仅有化合物库，我们致力于为*科研客户提供前沿的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药 Patent 收录了MCE客户的科研成果；
•   专业团队跟踪新的制药及生命科学研究进展，为您提供*新的活性化合物；
•   与世界各大制药公司及*科研机构建立了长期的合作。