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(2-Chloropyridin-4-yl)methanamine hydrochloride

CAS No. : 916210-98-5

产品活性：(2-Chloropyridin-4-yl)methanamine hydrochloride is a selective LOXL2 inhibitor with an IC₅₀ of 126 nM.

研究领域：Neuronal Signaling

作用靶点：Monoamine Oxidase

In Vitro: (2-Chloropyridin-4-yl)methanamine hydrochloride is shown to be selective for LOXL2 over LOX and three other amine oxidases (MAO-A, MAO-B and SSAO). In the human whole blood LOXL2 assay, (2-Chloropyridin-4-yl)methanamine hydrochloride has an IC₅₀ of 1.45 µM compared to 126 nM in the absence of blood proteins. (2-Chloropyridin-4-yl)methanamine hydrochloride shows a 31-fold selectivity for LOXL2+BSA (IC₅₀=190 nM) over LOX+BSA (IC₅₀=5.91 µM). Against a panel of non-LTQ-containing AO enzymes (MAO-A, MAO-B and SSAO), LOXL2-IN-1 is found to be inactive at 30 µM. (2-Chloropyridin-4-yl)methanamine hydrochloride is profiled for the inhibition of three different CYP enzymes (CYPs 3A4, 2C9 and 2D6) and in each case the IC₅₀ is more than 30 µM.

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