目录:MedChemExpress LLC>>生化试剂>> SRI-011381 hydrochloride | MCE
CAS | 2070014-88-7 | 纯度 | 99.97% |
---|---|---|---|
分子量 | 365.94 | 分子式 | C₂₀H₃₂ClN₃O |
供货周期 | 现货 | 规格 | 5 mg |
货号 | HY-100347A | 应用领域 | 医疗卫生,化工,生物产业,制药/生物制药 |
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CAS No. : 2070014-88-7
产品活性:SRI-011381 hydrochloride is an orally active TGF-β signaling agonist, exhibits neuroprotective effects.
研究领域:Stem Cell/Wnt | TGF-beta/Smad
作用靶点:TGF-beta/Smad
In Vitro: SRI-011381 (10 μM) hydrochloride promotes the proliferation of mouse lung fibroblasts, and significantly increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
In Vivo: SRI-011381 (30 mg/kg; i.p.; every 2 d; for 22 days) hydrochloride partially rescues the deficits in optic nerve and retina of YAPGFAP-CKO EAE mice.
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