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Glumetinib

CAS No. : 1642581-63-2

产品活性：Glumetinib (SCC244) is a highly selective, orally bioavailable, ATP-competitive c-Met inhibitor with an IC₅₀ of 0.42 nM. Glumetinib has greater than 2400-fold selectivity for c-Met over those 312 kinases evaluated, including the c-Met family member RON and highly homologous kinases Axl, Mer, TyrO3. Antitumor activity.

研究领域：Protein Tyrosine Kinase/RTK

作用靶点：c-Met/HGFR

In Vitro: Glumetinib (SCC244) (0-10 nM; 72 hours) elicits selective and profound effects against c-Met–driven cancer cell proliferation.
Glumetinib (0-50 nM; 24 hours) induces G1–S phase cell-cycle arrest in c-Met–addicted human cancer cells.

In Vivo: Glumetinib (2.5-10 mg/kg; p.o.; once daily for 2-3 weeks) significantly inhibits c-Met–driven tumor growth in cancer CDX models.
Glumetinib shows significant antitumor efficiency in NSCLC and HCC tumor PDX models with MET aberration.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Kinase Inhibitor Library  |  Protein Tyrosine Kinase Compound Library  |  Anti-Cancer Compound Library  |  Clinical Compound Library  |  Drug Repurposing Compound Library  |  Orally Active Compound Library  |  Anti-Lung Cancer Compound Library  |  Angiogenesis-Related Compound Library  |  Anti-Liver Cancer Compound Library   |  Rare Diseases Drug Library  |  Anti-Colorectal Cancer Compound Library   |  Cancer Stem Cells Compound Library  |  Heterocyclic Compound Library  |  Membrane Protein-targeted Compound Library  |  Membrane Receptor-targeted Compound Library  |  AMG-208  |  DS-1205b free base  |  c-Met-IN-1  |  Savolitinib  |  c-Met-IN-11  |  ABN401  |  Foretinib  |  Bafisontamab  |  MK-2461  |  Dalmelitinib  |  MK-8033 hydrochloride  |  c-Met-IN-12  |  MET kinase-IN-4  |  Cabozantinib  |  AC-386  |  c-Met inhibitor 1  |  Pamufetinib  |  Tyrosine kinase-IN-4  |  PHA-665752  |  JNJ-38877618  |  SU11274  |  AMG-458  |  SCR-1481B1  |  Mifanertinib dimaleate  |  c-Met-IN-2  |  Cabozantinib-d₄  |  c-Met-IN-13

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