MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

MKK7-COV-9

CAS No. : 2283355-59-7

产品活性：MKK7-COV-9 is a potent and selective covalent inhibitor of MKK7 and targets a specific protein–protein interaction of MKK7. MKK7-COV-9 blocks primary B cell activation in response to LPS with an EC₅₀ of 4.98 μM.

研究领域：MAPK/ERK Pathway

作用靶点：p38 MAPK

In Vitro: Due to poor permeability, the piperidine analogs MKK7-COV-10 and MKK7-COV-11 proves to be inactive in ICW in 3T3 cells, as well as the carboxylic acid MKK7-COV-8. In contrast, as an amide counterpart , MKK7-COV-9, retains activity (EC₅₀=4.06 μM) and furthermore now provides a new vector for further derivatization.
MKK7-COV-9 (10 μM; 48 hours) shows limited cytotoxic effect only at the highest tested concentration. Only one cell line, HCT116, displayed half-maximal lethal dose (LD₅₀)<10 μM for these two compounds.
MKK7-COV-9 (10 μM; 2 hr pre-incubation) is able to inhibit 60% of the CD86⁺ response in response to LPS stimulation, in primary mouse B cells , except the negative control MKK7-NEG-1.
JNK is known to mediate activation of B cells in response to lipopolysaccharide (LPS; HY-D1056) through the TLR4 signaling pathway.
MKK7-COV-9 (0-10 μM; 2 hr pre-incubation) is able to mediate activation of B cells in response to LPS through the TLR4 signaling pathway, it shows a dose-response curves for inhibition of LPS induced activation and exhibits an EC₅₀ value of 4.98 μM.(EC₅₀=4.98 μM for MKK7-COV-12; EC₅₀>10 μM for MKK7-COV-7; EC₅₀=2.23 μM for JNK-IN-8).

相关产品：Covalent Screening Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  Kinase Inhibitor Library  |  MAPK Compound Library  |  Anti-Cancer Compound Library  |  Covalent Screening Library  |  Reprogramming Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Anti-Lung Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Neurodegenerative Disease-related Compound Library  |  Anti-Obesity Compound Library  |  Angiogenesis-Related Compound Library  |  Antidepressant Compound Library  |  Anti-Prostate Cancer Compound Library  |  Anti-Pulmonary Fibrosis Compound Library  |  Heterocyclic Compound Library  |  Pain-Related Compound Library  |  Membrane Protein-targeted Compound Library  |  Bisabolangelone  |  4-Hydroxylonchocarpin  |  TLR4/NF-κB/MAPK-IN-1  |  Broussonin E  |  L-threo-Sphingosine  |  SB 242235  |  Hydrangenol  |  EGF-R (661-681) T669 Peptide  |  TA-01  |  AMG-548 hydrochloride  |  JX401  |  Ganoderterpene A  |  VX-702  |  Esculin  |  R1487 Hydrochloride  |  Emprumapimod  |  BMS-751324  |  p38α inhibitor 3  |  Anti-inflammatory agent 7  |  Atraric acid  |  BMS-582949 hydrochloride  |  Ferulic acid methyl ester  |  Dilmapimod  |  Gossypetin  |  Pamapimod  |  Andrograpanin  |  (Rac)-Hesperetin  |  Lucidone  |  PF-03715455  |  AMG-47a

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种*仅有化合物库，我们致力于为*科研客户提供前沿的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药 Patent 收录了MCE客户的科研成果；
•   专业团队跟踪新的制药及生命科学研究进展，为您提供*新的活性化合物；
•   与世界各大制药公司及*科研机构建立了长期的合作。