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Emavusertib

CAS No. : 1801344-14-8

产品活性：Emavusertib (CA-4948) is a potent IRAK4/FLT3 inhibtor with anti-tumor activity.

研究领域：Immunology/Inflammation  |  Protein Tyrosine Kinase/RTK

作用靶点：IRAK  |  FLT3

In Vitro: Emavusertib (CA-4948) is over 500-fold more selective for IRAK-4 compared to IRAK-1. Emavusertib reduces TNF-α, IL-1β, IL-6 and IL-8 release from TLR-Stimulated THP-1 Cells with an IC₅₀ <250 nM. Emavusertib also has antiproliferative activity due to inhibition of receptor-type tyrosine-protein kinase FLT3.

In Vivo: Emavusertib (CA-4948) shows anti-tumor activity in animal models including tumors containing MyD88 gene mutations. Emavusertib shows antileukemic activity in mouse models of FLT3 wild-type and FLT3 mutated acute myeloid leukemia (AML).

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