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MPTP hydrochloride

CAS No. : 23007-85-4

产品活性：MPTP hydrochloride is a brain penetrant dopamine neurotoxin, inducing Parkinson’s Disease. MPTP hydrochloride, a precusor of MPP⁺, induces apoptosis.

研究领域：GPCR/G Protein  |  Neuronal Signaling  |  Apoptosis

作用靶点：Dopamine Receptor  |  Apoptosis

In Vitro: Pretreatment with 50 mM 4-phenylpyridine, reduces IC₅₀ (concentration for 50% inhibition of twitch amplitude) values of MPTP from 53 to 18 mM and d-tubocurarine from 0.7 to 0.3 mM, respectively, in mouse phrenic nerve-diaphragm.

In Vivo: The toxic effect of MPTP can be completely abolished in vivo by treatment with a monoamine oxidase inhibitor and potentiated by an inhibitor of catechol-O-methyltransferase. Gas1 expressions are significantly elevated in the majority of the reactive astrocytes of the brains with LPS or MPTP insults in animal models.

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