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Atuveciclib S-Enantiomer

CAS No. : 2250279-81-1

产品活性：Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is a potent and selective CDK9 inhibitor, which inhibits CDK9/CycT1 with an IC₅₀ of 16 nM.

研究领域：Cell Cycle/DNA Damage

作用靶点：CDK

In Vitro: In comparison with Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties, well within the limits of measurement accuracy; however, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC₅₀ CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC₅₀: 1100 nM) .

In Vivo: Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios of about 1. Relative to Atuveciclib (BAY-1143572), Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar rat PK properties in vivo (CL_b: 1.2 L/kg per hour, V_ss: 1.2 L/kg, t_1/2: 0.6 h, F: 53 %).

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