MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

PAC

CAS No. : 2158322-33-7

产品活性：PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab).

研究领域：Vitamin D Related/Nuclear Receptor  |  PROTAC  |  Antibody-drug Conjugate/ADC Related

作用靶点：Estrogen Receptor/ERR  |  PROTAC-Linker Conjugates for PAC

In Vitro: Treatment of HER2 expressing cells with HER2 antibody containing PAC Anti-HER2(Endox-XIAP) results in a marked decreased Estrogen Receptor-alpha (ERα) levels with an IC₅₀ of 132 ng/mL. The PROTAC-Antibody Conjugate (PAC) molecules comprise an antibody conjugated via a linker (L1) to a PROTAC, wherein the PROTAC comprises an ubiquitin E3 ligase binding group (“E3LB"), a linker (“L2") and a protein binding group (“PB"). The following sections describe the components that comprise the PAC. To obtain a PAC having potent efficacy and a desirable therapeutic index, the following components are provided. 1. Antibody (Ab): The antibody portion of a PAC can target a cell that expresses an antigen whereby the antigen specific PAC is delivered intracellularly to the target cell, typically through endocytosis While PACs that comprise an antibody directed to an antigen that is not found on the cell surface may result in less specific intracellular delivery of the PROTAC portion into the cell, the PAC may still undergo pinocytosis. 2. Linkers (L1): A“linker" (L1) is a bifunctional or multifunctional moiety that can be used to link one or more PROTAC moieties (D) to an antibody (Ab) to form a PAC. In some embodiments, PACs can be prepared using a L1 having reactive functionalities for covalently attaching to the PROTAC and to the antibody. 3. PROTAC(D) .

相关产品：Estradiol hemihydrate  |  OP-1074  |  GSK-4716  |  LSD1/ER-IN-1  |  Avobenzone  |  Cholesterol-¹³C₂  |  Cholesterol-¹⁸O  |  Diethylstilbestrol  |  ERB-196  |  FLTX1  |  Raloxifene hydrochloride  |  Tamoxifen  |  Estradiol-d₂-1  |  Bazedoxifene acetate  |  FSHR agonist 1  |  Estrone sulfate sodium  |  GNE-502  |  β-Estradiol 17-acetate  |  Enclomiphene  |  AhR modulator-1  |  α-Zearalenol  |  SNIPER(ER)-87  |  ERRα antagonist-2  |  Estradiol-d₂  |  Cholesterol-d₇  |  PROTAC BRD4 Degrader-5-CO-PEG3-N3  |  (Rac)-Hexestrol-d₄  |  Cholesterol-d  |  (E)-4-Hydroxytamoxifen

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种*仅有化合物库，我们致力于为*科研客户提供前沿的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药 Patent 收录了MCE客户的科研成果；
•   专业团队跟踪新的制药及生命科学研究进展，为您提供*新的活性化合物；
•   与世界各大制药公司及*科研机构建立了长期的合作。