目录:MedChemExpress LLC>>生化试剂>> PF-04979064 | MCE
| CAS | 1220699-06-8 | 纯度 | 99.83% |
|---|---|---|---|
| 分子量 | 446.5 | 分子式 | C₂₄H₂₆N₆O₃ |
| 供货周期 | 现货 | 规格 | 5 mg |
| 货号 | HY-100398 | 应用领域 | 医疗卫生,化工,生物产业,制药/生物制药 |
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CAS No. : 1220699-06-8
产品活性：PF-04979064 is a potent and selective PI3K/mTOR dual kinase inhibitor with Kis of 0.13 nM and 1.42 nM for PI3Kα and mTOR, respectively.
研究领域：PI3K/Akt/mTOR
作用靶点：PI3K | mTOR
In Vitro: PF-04979064 is tested against human class I PI3K isoforms PI3Kα, PI3Kγ, and PI3Kδ, with PI3Kα Ki of 0.13 nM, PI3Kγ Ki of 0.111 nM, and PI3Kδ Ki of 0.122 nM.
In Vivo: PF-04979064 is progressed to rat in vivo PK studies and exhibits robust PK profile: Vdss=5.23 L/kg, Cl=19.3 mL/min/kg, T1/2=1.85 h, and F%=61%.
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