目录:MedChemExpress LLC>>生化试剂>> Inarigivir ammonium | MCE
| CAS | 2172788-92-8 | 纯度 | 99.04% |
|---|---|---|---|
| 分子量 | 604.53 | 分子式 | C₂₀H₂₉N₈O₁₀PS |
| 供货周期 | 现货 | 规格 | 5 mg |
| 货号 | HY-101954A | 应用领域 | 医疗卫生,化工,生物产业,制药/生物制药 |
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CAS No. : 2172788-92-8
产品活性：Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses.
研究领域：Anti-infection
作用靶点：HBV
In Vitro: Inarigivir (SB 9200) is active against HBV variants carrying resistance markers against all the nucleos(t)ide analogues approved for treating chronic hepatitis B.
In Vivo: Inarigivir (100 mg/kg/day, ip) significantly reduces viral DNA in the liver and shows anti-HBV activity. Serum HBV DNA is not reduced in response to treatment. Inarigivir does not affect levels of HBV RNA in liver, levels of HBeAg in serum, or mean titers of HBsAg. The minimal effective dose is identified to be between 1.6 and 0.5 mg/kg/day using liver HBV DNA values.
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