参考价	￥ 3000

生化试剂

MedChemExpress (M

纯度	99.22%	分子量	522.31
分子式	C₂₅H₂₆ClN₅O₂.₈/₅HCl	供货周期	现货
规格	5 mg	货号	HY-122181B
应用领域	医疗卫生,化工,生物产业,制药/生物制药

OTS186935 hydrochloride | MCEOTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC50 of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells[1].

详细介绍

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

OTS186935 hydrochloride

CAS No. :

产品活性：OTS186935 hydrochloride is a potent protein methyltransferase SUV39H2 inhibitor with an IC₅₀ of 6.49 nM. OTS186935 hydrochloride shows significant inhibition of tumor growth in mouse xenograft models without any detectable toxicity. OTS193320 hydrochloride regulates the production of γ-H2AX in cancer cells.

研究领域：Epigenetics

作用靶点：Histone Methyltransferase

In Vitro: OTS186935 hydrochloride inhibits A549 cell growth with an IC₅₀ of 0.67 μM.

In Vivo: OTS186935 hydrochloride (10 mg/kg or 25 mg/kg; intravenously; once daily for 14 days) exhibits growth suppressive effects in human cancer cell line derived xenograft models.

相关产品：Bioactive Compound Library Plus | Epigenetics Compound Library | Histone Modification Research Compound Library | Anti-Cancer Compound Library | Reprogramming Compound Library | Anti-Blood Cancer Compound Library | Targeted Diversity Library | Heterocyclic Compound Library | Membrane Protein-targeted Compound Library | PRMT5-IN-17 | EZM0414 | BIX-01294 | WDR5-IN-5 | PRMT5-IN-22 | Gambogenic acid | SGC707 | Dot1L-IN-7 | MS1943 | PRMT5-IN-21 | NSD3-IN-3 | DCLX069 | MAK683 | DS-437 | EPZ020411 | WDR5-IN-4 TFA | Amodiaquine dihydrochloride | Furamidine | SMYD3-IN-2 | UNC0642 | Chaetocin | UNC0646 | UNC0224 | EBI-2511 | BVT948 | MM-401 | CMP-5 | EPZ-719

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种*仅有化合物库，我们致力于为*科研客户提供前沿的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药 Patent 收录了MCE客户的科研成果；
•   专业团队跟踪新的制药及生命科学研究进展，为您提供*新的活性化合物；
•   与世界各大制药公司及*科研机构建立了长期的合作。