MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Laduviglusib (GMP)

CAS No. : 252917-06-9

产品活性：Laduviglusib (CHIR-99021) (GMP) is Laduviglusib (HY-10182) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Laduviglusib is a potent, orally active and selective GSK-3α/β inhibitor.

研究领域：PI3K/Akt/mTOR  |  Stem Cell/Wnt  |  Autophagy

作用靶点：GSK-3  |  Wnt  |  β-catenin  |  Autophagy

In Vitro: Laduviglusib (GMP) (20 μM, 21 days) transdifferentiates mouse fibroblasts to neurons (determined by increased number of TAUEGFP-/TUJ1-positive neuronal cells).
Laduviglusib (GMP) (3-5 μM, 2 days) induces somatic cells differentiation of pluripotent stem (PS) cells (the detailed method refers to the reference).
Laduviglusib (GMP) (12 μM, 5 days) converts human fibroblasts (HFF) into functional cardiomyocytes.
Laduviglusib (GMP) (3 μM, 4 days, hESCs) activates the canonical WNT signaling pathway, confirmed by β-catenin translocation into the nucleus.
Laduviglusib (GMP) (in MEFs expressing MyoD) enhances the marked increase in the number of proliferative cells led by RepSox (GMP) (HY-13012G) together with Forskolin (HY-15371).
Laduviglusib (GMP) (5 μM, 1 day) can be used to generate islets (hCiPSC-islets) from human chemically induced pluripotent stem cells (hCiPSC).

相关产品：BRD5648  |  CDK8-IN-11  |  AR-A014418  |  GSK-3β inhibitor 3  |  FzM1  |  SAR502250  |  Wnt/β-catenin agonist 3 hydrochloride  |  Pamidronic acid  |  GSK 3 Inhibitor IX  |  NRX-252114  |  K00546  |  Fz7-21  |  GSK-3β inhibitor 10  |  NSC668036  |  DIF-3  |  JW67  |  Ipafricept  |  (E)-Ferulic acid  |  Ipivivint  |  UU-T01  |  JW74  |  IQ 1  |  Heparan Sulfate  |  GSK3-IN-2  |  L-Quebrachitol  |  ETC-159  |  HLY78  |  Wnt/β-catenin agonist 2  |  RGB-286638  |  Cardiogenol C hydrochloride

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物  |  寡核苷酸  |  抗体  |  点击化学

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides  |  Antibodies  |  Click Chemistry

品牌介绍:
•   MCE (MedChemExpress) 拥有200 多种*仅有化合物库，我们致力于为*科研客户提供前沿的高品质小分子活性化合物；
•   50,000 多种高选择性抑制剂、激动剂涉及各热门信号通路及疾病领；
•   产品种类涵盖各种重组蛋白，多肽，常用试剂盒 ，更有 PROTAC、ADC 等特色产品，广泛应用于新药研发、生命科学等科研项目；
•   提供虚拟筛选，离子通道筛选，代谢组学分析检测分析，药物筛选等专业技术服务；
•   设有专业的实验中心和严格的质控、验证体系；
•   提供 LC/MS、NMR、HPLC、手性分析、元素分析等各项质检报告，确保产品的高纯度、高品质；
•   产品的生物活性多经各国客户实验验证；
•   Nature, Cell, Science 等多种顶级期刊及制药 Patent 收录了MCE客户的科研成果；
•   专业团队跟踪新的制药及生命科学研究进展，为您提供*新的活性化合物；
•   与世界各大制药公司及*科研机构建立了长期的合作。