参考价	￥ 450

生化试剂

MedChemExpress (M

CAS	104594-70-9	纯度	99.96%
分子量	284.31	分子式	C₁₇H₁₆O₄
供货周期	现货	规格	5 mg
货号	HY-N0274	应用领域	医疗卫生,化工,生物产业,制药/生物制药

Caffeic acid phenethyl ester | MCECaffeic acid phenethyl ester is a <b>NF-κB</b> inhibitor.

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Caffeic acid phenethyl ester

CAS No. : 104594-70-9

产品活性：Caffeic acid phenethyl ester is a NF-κB inhibitor.

研究领域：NF-κB | Apoptosis

作用靶点：NF-κB | Apoptosis

结构分类：苯丙素类 | 简单苯丙素 | 酚类 | 多酚类

In Vitro: Caffeic acid phenethyl ester is a NF-κB inhibitor. Cell survival and proliferation of CRPC cell lines are all significantly suppressed by Caffeic acid phenethyl ester (CAPE) treatment dose-dependently. The growth inhibitory effect of Caffeic acid phenethyl ester is evident within 24 hours of treatment but the suppressive effect accumulates over time. The IC₅₀ of 24, 48, 72, and 96 h Caffeic acid phenethyl ester treatment on LNCaP 104-R1 cells is 64.0, 30.5, 20.5, and 18.0 μM, respectively. Colony formation assay reveals that treatment with 10 μM Caffeic acid phenethyl ester reduces colony formation of LNCaP 104-R1 cells by 90% while treatment with 20 μM Caffeic acid phenethyl ester completely blocks the formation of LNCaP 104-R1 colonies. Flow cytometric analysis reveals a reduction of cells in the S phase and G2/M phase but an increase of cells in the G1 phase population in LNCaP 104-R1 cells under Caffeic acid phenethyl ester treatment. Caffeic acid phenethyl ester treatment also significantly decreases protein levels of fatty acid synthase (FAS), retinoblastoma protein (Rb), phospho-Rb Ser807/811, c-Myc, p70S6kinase, phospho-p70S6kinase Thr421/Ser424, Skp2, p90RSK, and NF-κB p65.

In Vivo: Administration of Caffeic acid phenethyl ester (CAPE) by gavage (10 mg/kg body weight per day) for eight weeks results in 50% reduction of tumor volume, suggesting that Caffeic acid phenethyl ester treatment retards the growth of LNCaP 104-R1 xenografts. Caffeic acid phenethyl ester gavage slows down the tumor growth of LNCaP 104-R1 cells, which is consistent with our observation that Caffeic acid phenethyl ester treatment induces cell cycle arrest but not apoptosis.

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