参考价	￥ 500

生化试剂

MedChemExpress (M

CAS	18916-17-1	纯度	99.65%
分子量	582.55	分子式	C₂₇H₃₄O₁₄
供货周期	现货	规格	500 mg
货号	HY-N0119	应用领域	医疗卫生,化工,生物产业,制药/生物制药

Naringin Dihydrochalcone | MCENaringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses <b>NF-κB</b> signaling pathway.

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Naringin Dihydrochalcone

CAS No. : 18916-17-1

产品活性：Naringin Dihydrochalcone is an artificial sweetener derived from naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. Naringin exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringin suppresses NF-κB signaling pathway.

研究领域：NF-κB

作用靶点：NF-κB

结构分类：黄酮类 | 二氢查耳酮 | 酚类 | 多酚类

来源：植物 | 其他科

In Vitro: Naringin suppresses NF-κ B signaling pathway activation. Naringenin inhibits high glucose-induced proliferation, inflammatory reaction and oxidative stress injury in HBZY-1 cells. Naringin inhibits AGS cancer cell proliferation in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin induces autophagic cell death in AGS cells. Naringin activated the autophagy related protein in AGS cells. Naringin protects PC12 cells from 3-NP neurotoxicity. The lactate dehydrogenase release is decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione.

In Vivo: Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px. Oral administration of naringin significantly improves the learning and memory abilities. Naringin significantly enhances insulin signaling pathway.

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