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Costunolide

CAS No. : 553-21-9

产品活性：Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells.

研究领域：Apoptosis  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Endogenous Metabolite

结构分类：萜类  |  倍半萜

来源：植物  |  菊科  |  广木香

In Vitro: Costunolide inhibits the colony formation, migrative and invasive abilities of the H1299 cells in a dose or time dependent manner.
Costunolide (6.7-215.2 μM; 24 hours) inhibits the viability of H1299 cells in a dose-dependent manner, with an IC₅₀ of 23.93 µM.
Costunolide (12.0-48.0 µM; 48 hours) induces apoptosis in H1299 cells.
Costunolide (12-48.0 µM; 6-12 hours) regulates metastasis- and proliferation-associated mRNA expression.
Costunolide regulates epithelial-to-mesenchymal transition (EMT)-associated protein expression.
Costunolide regulates c-Myc mediated apoptosis signaling and 14-3-3-mediated signaling pathways in breast cancer cells.

In Vivo: Costunolide (20 mg/kg; i.p; daily; for 30 days) inhibits breast cancer through c-Myc/p53 and AKT/14-3-3 pathway.

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