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Reticuline

CAS No. : 485-19-8

产品活性：Reticuline shows anti-inflammatory effects through JAK2/STAT3 and NF-κB signaling pathways. Reticuline inhibits mRNA expressions of TNF-α, and IL-6 and reduces the phosphorylation levels of JAK2 and STAT3. Reticuline exhibits cardiovascular effects.

研究领域：Epigenetics  |  Protein Tyrosine Kinase/RTK  |  JAK/STAT Signaling  |  Stem Cell/Wnt  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：JAK  |  STAT  |  NF-κB  |  Endogenous Metabolite

结构分类：生物碱  |  异喹啉类生物碱  |  酚类  |  多酚类  |  结构分类

来源：植物  |  樟科  |  乌药

In Vitro: Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) inhibits in a concentration-dependent manner the contractions induced by Phenylephrine (1 μM), KCl (80 mM) and KCl (30 mM), (IC₅₀=40±10, 240±40 and 300±40 μM, respectively) in isolated rat aortic rings with intact endothelium.
Reticuline (3 μM, 30 μM, 300 μM, 900 μM and 1.5 mM) antagonizes CaCl₂-induced contractions, and also inhibits the intracellular calcium dependent transient contractions induced by Norepinephrine (1μM), but not those induced by Caffeine (20 mM).

In Vivo: Reticuline (5, 10 and 20 mg/kg, i. v., randomly) injections produced an intense hypotension in normotensive rats. The hypotensive effect of Reticuline is probably due to a peripheral vasodilation in consequence of: 1) muscarinic stimulation and NOS activation in the vascular endothelium, 2) voltage-dependent Ca²⁺ channel blockade and/or 3) inhibition of Ca²⁺ release from norepinephrine-sensitive intracellular stores.

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